Bioerodible polymers with a phosphorus-nitrogen backbone

H. R. Allcock; S. Kwon; S. R. Pucher

Bioerodible polymers with a phosphorus-nitrogen backbone

H. R. Allcock, S. Kwon, S. R. Pucher

Research output: Contribution to journal › Conference article › peer-review

Abstract

Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

Original language	English (US)
Pages (from-to)	180-181
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	31
Issue number	2
State	Published - Aug 1 1990
Event	Papers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA Duration: Aug 26 1990 → Aug 31 1990

All Science Journal Classification (ASJC) codes

Materials Science(all)
Polymers and Plastics
Engineering(all)

Cite this

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title = "Bioerodible polymers with a phosphorus-nitrogen backbone",

abstract = "Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.",

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TY - JOUR

T1 - Bioerodible polymers with a phosphorus-nitrogen backbone

AU - Allcock, H. R.

AU - Kwon, S.

AU - Pucher, S. R.

PY - 1990/8/1

Y1 - 1990/8/1

N2 - Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

AB - Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

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M3 - Conference article

AN - SCOPUS:0025474930

SN - 0032-3934

VL - 31

SP - 180

EP - 181

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 2

T2 - Papers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry

Y2 - 26 August 1990 through 31 August 1990

ER -

Bioerodible polymers with a phosphorus-nitrogen backbone

Abstract

All Science Journal Classification (ASJC) codes

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