Bioinspired super-strong aqueous synthetic tissue adhesives

Qing Li, Wei Song, Jinghui Li, Chuying Ma, Xinxiang Zhao, Jianlin Jiao, Oliver Mrowczynski, Becky S. Webb, Elias B. Rizk, Di Lu, Chao Liu

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.

Original languageEnglish (US)
Pages (from-to)933-956
Number of pages24
Issue number3
StatePublished - Mar 2 2022

All Science Journal Classification (ASJC) codes

  • General Materials Science


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