Bioinspired super-strong aqueous synthetic tissue adhesives

Qing Li; Wei Song; Jinghui Li; Chuying Ma; Xinxiang Zhao; Jianlin Jiao; Oliver Mrowczynski; Becky S. Webb; Elias B. Rizk; Di Lu; Chao Liu

doi:10.1016/j.matt.2021.12.018

Bioinspired super-strong aqueous synthetic tissue adhesives

Qing Li, Wei Song, Jinghui Li, Chuying Ma, Xinxiang Zhao, Jianlin Jiao, Oliver Mrowczynski, Becky S. Webb, Elias B. Rizk, Di Lu, Chao Liu

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.

Original language	English (US)
Pages (from-to)	933-956
Number of pages	24
Journal	Matter
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.matt.2021.12.018
State	Published - Mar 2 2022

All Science Journal Classification (ASJC) codes

General Materials Science

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10.1016/j.matt.2021.12.018

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title = "Bioinspired super-strong aqueous synthetic tissue adhesives",

abstract = "Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.",

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AU - Song, Wei

AU - Li, Jinghui

AU - Ma, Chuying

AU - Zhao, Xinxiang

AU - Jiao, Jianlin

AU - Mrowczynski, Oliver

AU - Webb, Becky S.

AU - Rizk, Elias B.

AU - Lu, Di

AU - Liu, Chao

PY - 2022/3/2

Y1 - 2022/3/2

N2 - Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.

AB - Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues. Herein, we report a strategy for designing a biodegradable, super-strong aqueous glue (B-Seal) for surgical uses, inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super strong, and elastic adhesive sealant composed of injectable waterborne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective CSF leak prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction for designing the next-generation wet tissue adhesives for surgeries.

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Bioinspired super-strong aqueous synthetic tissue adhesives

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