TY - JOUR
T1 - Biologic characteristics of four Ewing's sarcomas
AU - Workman, M. Linda
AU - Soukup, Shirley W.
AU - Neely, John E.
AU - Whitsett, Jeffrey
AU - Ballard, Edgar
AU - Lampkin, Beatrice
N1 - Funding Information:
We would like to acknowledge the excellent technical assistance of Marianne Brown and Jeffrey Burdsall. We would like to thank Maureen McCarthy and Fay Walker for their help in the preparation of this manuscript. Supported in part by the Lindner Fund for Ewing's Sarcoma Research.
PY - 1985/2/15
Y1 - 1985/2/15
N2 - Four Ewing's sarcomas were examined for chromosomal characteristecs, growth in cell culture, tumorigenicity in nude mice, and presence of β-adrenergic receptors. Three tumors were from untreated patients (one obtained directly from the patient and two after growth in nude mice) and one was a metastatic lesion obtained after treatment. All four tumors were diploid or near-diploid, with one or more structural rearrangements. In the metastatic lesion. 21 abnormalities were seen. No specific chromosome aberration was found to be common to all four tumors, although a t(1,16) was observed in two and a t(11;22) in two. Abnormalities involving chromosomes #1, #3, #11, #13, #16, and #22 were each found in two of four tumors. All four tumors were tumorigenic in nude mice; two grew well in cell culture, one of which became an established line, and all four expressed high concentrations of β-adrenergic receptors.
AB - Four Ewing's sarcomas were examined for chromosomal characteristecs, growth in cell culture, tumorigenicity in nude mice, and presence of β-adrenergic receptors. Three tumors were from untreated patients (one obtained directly from the patient and two after growth in nude mice) and one was a metastatic lesion obtained after treatment. All four tumors were diploid or near-diploid, with one or more structural rearrangements. In the metastatic lesion. 21 abnormalities were seen. No specific chromosome aberration was found to be common to all four tumors, although a t(1,16) was observed in two and a t(11;22) in two. Abnormalities involving chromosomes #1, #3, #11, #13, #16, and #22 were each found in two of four tumors. All four tumors were tumorigenic in nude mice; two grew well in cell culture, one of which became an established line, and all four expressed high concentrations of β-adrenergic receptors.
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U2 - 10.1016/0165-4608(85)90165-7
DO - 10.1016/0165-4608(85)90165-7
M3 - Article
C2 - 2982475
AN - SCOPUS:0021922020
SN - 0165-4608
VL - 15
SP - 215
EP - 225
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 3-4
ER -
