Biologically active biotin derivatives of schweinfurthin F

Natalie C. Ulrich, Craig H. Kuder, Raymond J. Hohl, David F. Wiemer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.

Original languageEnglish (US)
Pages (from-to)6716-6720
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
StatePublished - Nov 15 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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