Biologically active biotin derivatives of schweinfurthin F

Natalie C. Ulrich; Craig H. Kuder; Raymond J. Hohl; David F. Wiemer

doi:10.1016/j.bmcl.2010.08.143

Biologically active biotin derivatives of schweinfurthin F

Natalie C. Ulrich, Craig H. Kuder, Raymond J. Hohl, David F. Wiemer

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.

Original language	English (US)
Pages (from-to)	6716-6720
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2010.08.143
State	Published - Nov 15 2010

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.08.143

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title = "Biologically active biotin derivatives of schweinfurthin F",

abstract = "As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.",

author = "Ulrich, {Natalie C.} and Kuder, {Craig H.} and Hohl, {Raymond J.} and Wiemer, {David F.}",

note = "Funding Information: We thank the UI Graduate College for support in the form of a Presidential Fellowship (to N.C.U.). Financial support from the Roy J. Carver Charitable Trust as a Research Program of Excellence and from the Roland W. Holden Family Program for Experimental Cancer Therapeutics is gratefully acknowledged. ",

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AU - Ulrich, Natalie C.

AU - Kuder, Craig H.

AU - Hohl, Raymond J.

AU - Wiemer, David F.

N1 - Funding Information: We thank the UI Graduate College for support in the form of a Presidential Fellowship (to N.C.U.). Financial support from the Roy J. Carver Charitable Trust as a Research Program of Excellence and from the Roland W. Holden Family Program for Experimental Cancer Therapeutics is gratefully acknowledged.

PY - 2010/11/15

Y1 - 2010/11/15

N2 - As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.

AB - As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Biologically active biotin derivatives of schweinfurthin F

Abstract

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