TY - JOUR
T1 - Bioprocess membrane technology
AU - van Reis, Robert
AU - Zydney, Andrew
N1 - Funding Information:
The authors gratefully acknowledge contributions and support from colleagues at Genentech, Inc., University of Delaware, Pennsylvania State University, Millipore Corporation, Pall Corporation, and GE Healthcare. Pellicon and Prostak are trademarks of Millipore Corporation. Ultipor, Ultipleat, and Mustang are trademarks of Pall Corporation. Sepharose is a trademark of GE Healthcare companies.
PY - 2007/7/5
Y1 - 2007/7/5
N2 - Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.
AB - Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.
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U2 - 10.1016/j.memsci.2007.02.045
DO - 10.1016/j.memsci.2007.02.045
M3 - Review article
AN - SCOPUS:34248591731
SN - 0376-7388
VL - 297
SP - 16
EP - 50
JO - Journal of Membrane Science
JF - Journal of Membrane Science
IS - 1-2
ER -