TY - JOUR
T1 - Bioreactor design for tendon/ligament engineering
AU - Wang, Tao
AU - Gardiner, Bruce S.
AU - Lin, Zhen
AU - Rubenson, Jonas
AU - Kirk, Thomas B.
AU - Wang, Allan
AU - Xu, Jiake
AU - Smith, David W.
AU - Lloyd, David G.
AU - Zheng, Ming H.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
AB - Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
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U2 - 10.1089/ten.teb.2012.0295
DO - 10.1089/ten.teb.2012.0295
M3 - Review article
C2 - 23072472
AN - SCOPUS:84874749402
SN - 1937-3368
VL - 19
SP - 133
EP - 146
JO - Tissue Engineering - Part B: Reviews
JF - Tissue Engineering - Part B: Reviews
IS - 2
ER -