Biosafety of low-intensity pulsed transcranial focused ultrasound brain stimulation - A human skull study

Mengyue Chen, Chang Peng, Taewon Kim, Pratik Y. Chhatbar, Marie Muller, Wuwei Feng, Xiaoning Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Among a variety of existing modalities for noninvasive brain stimulation (NIBS), low-intensity pulsed transcranial focused ultrasound (tFUS) is a promising technique to precisely stimulate deep brain structures due to its high spatial specificity and superior penetration depth. While tFUS is gaining momentum as an emerging NIBS technique, an advisable biosafety-associated combination of sonication parameters including duty cycle and power input remains to be explored. In this study, biosafety of low-intensity pulsed tFUS using various sonication parameters was evaluated by measuring acoustic intensities and temperature variations across a piece of real human skull. The results showed that ISPTA above 480 mW/cm2 is likely to induce an excessive temperature rise for a sonication duration of 160 seconds. Also, the skull base effect and ultrasound transducer self-heating effect should be noted during the sonication. Based on the findings in this study, an initial biosafety guide was discussed for the future investigation of ultrasound-mediated NIBS.

Original languageEnglish (US)
Title of host publicationHealth Monitoring of Structural and Biological Systems XV
EditorsPaul Fromme, Zhongqing Su
ISBN (Electronic)9781510640153
StatePublished - 2021
EventHealth Monitoring of Structural and Biological Systems XV 2021 - Virtual, Online, United States
Duration: Mar 22 2021Mar 26 2021

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceHealth Monitoring of Structural and Biological Systems XV 2021
Country/TerritoryUnited States
CityVirtual, Online

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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