TY - JOUR
T1 - Bismuth Subsalicylate in the Treatment of Chronic Diarrhea of Childhood
AU - Gryboski, Joyce D.
AU - Hillemeier, A. Craig
AU - Grill, Bruce
AU - Kocoshis, Samuel
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985/11
Y1 - 1985/11
N2 - Twenty‐nine infants and children, age 2–70 months with chronic diarrhea, were admitted to a double‐blind, parallel clinical trial. The subjects were randomly assigned to receive either a bismuth subsalicylate liquid or a placebo liquid formulation. Treatment was given for 7 days with dosage varied according to age. Analysis of the results showed that the subjects in the bismuth subsalicylate‐treated group gained significantly more weight (p < 0.05), had significantly fewer (p < 0.01) and firmer (p < 0.01) stools with less water content (p< 0.01) during the course of the study than did the placebo‐treated group. Response to treatment, as graded by nursing staff, family, and physicians was moderate to excellent in 86% of the treated group while none of the placebo group received such a rating (p <0.01). No differences were noted between stool weights or bile acid excretion.
AB - Twenty‐nine infants and children, age 2–70 months with chronic diarrhea, were admitted to a double‐blind, parallel clinical trial. The subjects were randomly assigned to receive either a bismuth subsalicylate liquid or a placebo liquid formulation. Treatment was given for 7 days with dosage varied according to age. Analysis of the results showed that the subjects in the bismuth subsalicylate‐treated group gained significantly more weight (p < 0.05), had significantly fewer (p < 0.01) and firmer (p < 0.01) stools with less water content (p< 0.01) during the course of the study than did the placebo‐treated group. Response to treatment, as graded by nursing staff, family, and physicians was moderate to excellent in 86% of the treated group while none of the placebo group received such a rating (p <0.01). No differences were noted between stool weights or bile acid excretion.
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U2 - 10.1111/j.1572-0241.1985.tb02013.x
DO - 10.1111/j.1572-0241.1985.tb02013.x
M3 - Article
C2 - 3901731
AN - SCOPUS:0022401525
SN - 0002-9270
VL - 80
SP - 871
EP - 876
JO - The American journal of gastroenterology
JF - The American journal of gastroenterology
IS - 11
ER -