Blank spots on the map: some current questions on nuclear organization and genome architecture

Carmen Adriaens, Leonid A. Serebryannyy, Marina Feric, Andria Schibler, Karen J. Meaburn, Nard Kubben, Pawel Trzaskoma, Sigal Shachar, Sandra Vidak, Elizabeth H. Finn, Varun Sood, Gianluca Pegoraro, Tom Misteli

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The past decades have provided remarkable insights into how the eukaryotic cell nucleus and the genome within it are organized. The combined use of imaging, biochemistry and molecular biology approaches has revealed several basic principles of nuclear architecture and function, including the existence of chromatin domains of various sizes, the presence of a large number of non-membranous intranuclear bodies, non-random positioning of genes and chromosomes in 3D space, and a prominent role of the nuclear lamina in organizing genomes. Despite this tremendous progress in elucidating the biological properties of the cell nucleus, many questions remain. Here, we highlight some of the key open areas of investigation in the field of nuclear organization and genome architecture with a particular focus on the mechanisms and principles of higher-order genome organization, the emerging role of liquid phase separation in cellular organization, and the functional role of the nuclear lamina in physiological processes.

Original languageEnglish (US)
Pages (from-to)579-592
Number of pages14
JournalHistochemistry and Cell Biology
Volume150
Issue number6
DOIs
StatePublished - Dec 1 2018

All Science Journal Classification (ASJC) codes

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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