TY - JOUR
T1 - Blastic natural killer cell lymphoma/leukemia
T2 - A report of seven cases
AU - Bayerl, Michael G.
AU - Rakozy, Christiane K.
AU - Mohamed, Anwar N.
AU - Vo, Trieu D.
AU - Long, Michael
AU - Eilender, David
AU - Palutke, Margarita
PY - 2002
Y1 - 2002
N2 - Only a few blastic natural killer (NK) cell leukemias and lymphomas have been reported. As such, the clinicopathologic spectrum of this disease is incompletely understood. We report 7 cases of blastic NK cell lymphoma/leukemia. All patients were men, 5 white and 2 Arab American. All cases exhibited blastic morphologic features and were CD3- and CD56+ with germline T-cell receptor genes. Five cases were CD4+ and involved the skin. Both CD4- cases never involved the skin. Other markers of mature NK cells such as CD16, CD57, and TIA-1 were expressed infrequently. Three cases were CD33+. One CD33+ case had a clonal rearrangement of the immunoglobulin heavy chain gene. Skin and lymph nodes were involved most often, with frequent evolution to a leukemic phase. Initial responses to therapy were achieved in most patients, but the tumors invariably recurred.
AB - Only a few blastic natural killer (NK) cell leukemias and lymphomas have been reported. As such, the clinicopathologic spectrum of this disease is incompletely understood. We report 7 cases of blastic NK cell lymphoma/leukemia. All patients were men, 5 white and 2 Arab American. All cases exhibited blastic morphologic features and were CD3- and CD56+ with germline T-cell receptor genes. Five cases were CD4+ and involved the skin. Both CD4- cases never involved the skin. Other markers of mature NK cells such as CD16, CD57, and TIA-1 were expressed infrequently. Three cases were CD33+. One CD33+ case had a clonal rearrangement of the immunoglobulin heavy chain gene. Skin and lymph nodes were involved most often, with frequent evolution to a leukemic phase. Initial responses to therapy were achieved in most patients, but the tumors invariably recurred.
UR - http://www.scopus.com/inward/record.url?scp=0036142942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036142942&partnerID=8YFLogxK
U2 - 10.1309/UUXV-YRL8-GXP7-HR4H
DO - 10.1309/UUXV-YRL8-GXP7-HR4H
M3 - Article
C2 - 11789729
AN - SCOPUS:0036142942
SN - 0002-9173
VL - 117
SP - 41
EP - 50
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 1
ER -