Blinded, controlled field trial of two commercially available mycoplasma bovis bacterin vaccines in veal calves

Marty K. Soehnlen, Adnan Aydin, Eugene Lengerich, Beth A. Houser, Ginger D. Fenton, Hannah R. Lysczek, Carolyn M. Burns, Louise I. Byler, Arthur L. Hattel, David R. Wolfgang, Bhushan M. Jayarao

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Mycoplasma bovis is an etiologic agent of pneumonia, arthritis, and otitis in young calves, such as those found in the special-fed veal industry. We conducted a blinded, controlled trial of two commercially available M. bovis bacterin vaccines for the prevention of respiratory disease in calves associated with M. bovis infection. Calves were randomly assigned to a subcutaneous treatment of vaccine A (n= 50), adjuvant A (n= 50), vaccine B (n= 50), or 0.9% sterile saline solution (n= 50) beginning at 27 days of age. Upper-respiratory tract colonization was not impacted by vaccination status. Vaccine A significantly reduced the presence of lung lesions (p= 0.0325), however there was no significant reduction of M. bovis in lung lesions. Vaccine B did not significantly reduce total lung lesions or M. bovis-specific lung lesions. The relative risk was determined to be 0.56, 1.0, and 1.36 for vaccine A, adjuvant A, and vaccine B, respectively. There was no association between the total specific antibody isotype (IgM, IgG1, IgG2, IgA) concentrations or M. bovis antibodies and the M. bovis-associated morbidity in the veal calves. Under the field conditions of this study, observed vaccine efficacy for vaccine A and vaccine B was 44% and less than 1%, respectively.

Original languageEnglish (US)
Pages (from-to)5347-5354
Number of pages8
Issue number33
StatePublished - Jul 26 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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