TY - JOUR
T1 - Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension
T2 - A Pediatric Nephrology Research Consortium Study
AU - Xiao, Nianzhou
AU - Starr, Michelle
AU - Stolfi, Adrienne
AU - Hamdani, Gilad
AU - Hashmat, Shireen
AU - Kiessling, Stefan G.
AU - Sethna, Christina
AU - Kallash, Mahmoud
AU - Matloff, Robyn
AU - Woroniecki, Robert
AU - Sanderson, Keia
AU - Yamaguchi, Ikuyo
AU - Cha, Stephen D.
AU - Semanik, Michael G.
AU - Chanchlani, Rahul
AU - Flynn, Joseph T.
AU - Mitsnefes, Mark
N1 - Publisher Copyright:
© 2023
PY - 2024/1
Y1 - 2024/1
N2 - Objective: To describe the blood pressure outcomes of infants admitted to the neonatal intensive care unit (NICU) with idiopathic (nonsecondary) hypertension (HTN) who were discharged on antihypertensive therapy. Study design: Retrospective, multicenter study of 14 centers within the Pediatric Nephrology Research Consortium. We included all infants with a diagnosis of idiopathic HTN discharged from the NICU on antihypertensive treatment. The primary outcome was time to discontinuation of antihypertensive therapy, grouped into (≤6 months, >6 months to 1 year, and >1 year). Comparisons between groups were made with χ2 tests, Fisher's exact tests, and ANOVA. Results: Data from 118 infants (66% male) were included. Calcium channel blockers were the most prescribed class of antihypertensives (56%) in the cohort. The percentages remaining on antihypertensives after NICU discharge were 60% at 6 months, 26% at 1 year, and 7% at 2 years. Antenatal steroid treatment was associated with decreased likelihood of antihypertensive therapy >1 year after discharge. Conclusions: This multicenter study reports that most infants admitted to the NICU diagnosed with idiopathic HTN will discontinue antihypertensive treatment by 2 years after NICU discharge. These data provide important insights into the outcome of neonatal HTN, but should be confirmed prospectively.
AB - Objective: To describe the blood pressure outcomes of infants admitted to the neonatal intensive care unit (NICU) with idiopathic (nonsecondary) hypertension (HTN) who were discharged on antihypertensive therapy. Study design: Retrospective, multicenter study of 14 centers within the Pediatric Nephrology Research Consortium. We included all infants with a diagnosis of idiopathic HTN discharged from the NICU on antihypertensive treatment. The primary outcome was time to discontinuation of antihypertensive therapy, grouped into (≤6 months, >6 months to 1 year, and >1 year). Comparisons between groups were made with χ2 tests, Fisher's exact tests, and ANOVA. Results: Data from 118 infants (66% male) were included. Calcium channel blockers were the most prescribed class of antihypertensives (56%) in the cohort. The percentages remaining on antihypertensives after NICU discharge were 60% at 6 months, 26% at 1 year, and 7% at 2 years. Antenatal steroid treatment was associated with decreased likelihood of antihypertensive therapy >1 year after discharge. Conclusions: This multicenter study reports that most infants admitted to the NICU diagnosed with idiopathic HTN will discontinue antihypertensive treatment by 2 years after NICU discharge. These data provide important insights into the outcome of neonatal HTN, but should be confirmed prospectively.
UR - https://www.scopus.com/pages/publications/85177197097
UR - https://www.scopus.com/inward/citedby.url?scp=85177197097&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2023.113765
DO - 10.1016/j.jpeds.2023.113765
M3 - Article
C2 - 37778410
AN - SCOPUS:85177197097
SN - 0022-3476
VL - 264
JO - Journal of Pediatrics
JF - Journal of Pediatrics
M1 - 113765
ER -