Body fat distribution and flow-mediated endothelium-dependent vasodilation in older men

L. J.O. Joseph; A. S. Ryan; J. Sorkin; C. Mangano; D. C. Brendle; M. C. Corretti; A. W. Gardner; L. I. Katzel

doi:10.1038/sj.ijo.0801972

Body fat distribution and flow-mediated endothelium-dependent vasodilation in older men

L. J.O. Joseph, A. S. Ryan, J. Sorkin, C. Mangano, D. C. Brendle, M. C. Corretti, A. W. Gardner, L. I. Katzel

Department of Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

OBJECTIVE: Recent studies indicate that abdominal fat accumulation, in particular intra-abdominal fat, is related to impaired endothelial function in young healthy volunteers. The aim of this study was to examine whether the distribution of body fat depots is related to impaired endothelial function in older men. METHODS: Cross-sectional sample of 38 older (68±1 y) sedentary (VO_2max=2.4±0.1 l/min) men. Flow-mediated endothelial dependent vasodilation (EDD) was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Abdominal subcutaneous and visceral fat depots were assessed by computed tomography scan (CT-scan) at the L₄-L₅ region in the supine position. Percentage body fat was assessed via dual-energy X-ray absorptiometry (DEXA). RESULTS: Flow-mediated percentage change in brachial artery was 7.64±0.7%, suggesting an impaired flow-mediated EDD. Using simple linear regression analysis, there were no statistically significant relationship observed between flow-mediated EDD and the indices of total and abdominal adiposity (percentage body fat=29.3±0.9%, r= -0.11; total abdominal fat area=465±23 cm², r= -0.1; intra-abdominal fat area=200±14 cm², r= -0.14; subcutaneous fat area=265±13 cm², r= -0.05; BMI=29.3±0.9 kg/m², r= -0.07; and waist to hip ratio=0.98±0.01, r= -0.20). CONCLUSION: These findings suggest that in older sedentary men there is no clear correlation between adiposity and body fat distribution and impairment of flow-mediated endothelium dependent vasodilation.

Original language	English (US)
Pages (from-to)	663-669
Number of pages	7
Journal	International Journal of Obesity
Volume	26
Issue number	5
DOIs	https://doi.org/10.1038/sj.ijo.0801972
State	Published - 2002

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Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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10.1038/sj.ijo.0801972

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@article{1927e7953762456e93a1c284ad144184,

title = "Body fat distribution and flow-mediated endothelium-dependent vasodilation in older men",

abstract = "OBJECTIVE: Recent studies indicate that abdominal fat accumulation, in particular intra-abdominal fat, is related to impaired endothelial function in young healthy volunteers. The aim of this study was to examine whether the distribution of body fat depots is related to impaired endothelial function in older men. METHODS: Cross-sectional sample of 38 older (68±1 y) sedentary (VO2max=2.4±0.1 l/min) men. Flow-mediated endothelial dependent vasodilation (EDD) was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Abdominal subcutaneous and visceral fat depots were assessed by computed tomography scan (CT-scan) at the L4-L5 region in the supine position. Percentage body fat was assessed via dual-energy X-ray absorptiometry (DEXA). RESULTS: Flow-mediated percentage change in brachial artery was 7.64±0.7%, suggesting an impaired flow-mediated EDD. Using simple linear regression analysis, there were no statistically significant relationship observed between flow-mediated EDD and the indices of total and abdominal adiposity (percentage body fat=29.3±0.9%, r= -0.11; total abdominal fat area=465±23 cm2, r= -0.1; intra-abdominal fat area=200±14 cm2, r= -0.14; subcutaneous fat area=265±13 cm2, r= -0.05; BMI=29.3±0.9 kg/m2, r= -0.07; and waist to hip ratio=0.98±0.01, r= -0.20). CONCLUSION: These findings suggest that in older sedentary men there is no clear correlation between adiposity and body fat distribution and impairment of flow-mediated endothelium dependent vasodilation.",

author = "Joseph, {L. J.O.} and Ryan, {A. S.} and J. Sorkin and C. Mangano and Brendle, {D. C.} and Corretti, {M. C.} and Gardner, {A. W.} and Katzel, {L. I.}",

note = "Funding Information: We would like to thank the patients who participated in this study. We would also like to thank the staff at the Department of Veterans Affairs Baltimore Geriatric Research, Education and Clinical Center for screening and recruiting. This work was supported by the Department of Veteran Affairs Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland; the University of Maryland Claude D Pepper Older Americans Independence Center (NIA P60 AG12583), a K24 mid-career development grant (K24 AG00930), an NIH training grant (T32 AG00219), and by a Special Emphasis Research Career Award (NIA K01 AG00657).",

year = "2002",

doi = "10.1038/sj.ijo.0801972",

language = "English (US)",

volume = "26",

pages = "663--669",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Body fat distribution and flow-mediated endothelium-dependent vasodilation in older men

AU - Joseph, L. J.O.

AU - Ryan, A. S.

AU - Sorkin, J.

AU - Mangano, C.

AU - Brendle, D. C.

AU - Corretti, M. C.

AU - Gardner, A. W.

AU - Katzel, L. I.

N1 - Funding Information: We would like to thank the patients who participated in this study. We would also like to thank the staff at the Department of Veterans Affairs Baltimore Geriatric Research, Education and Clinical Center for screening and recruiting. This work was supported by the Department of Veteran Affairs Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland; the University of Maryland Claude D Pepper Older Americans Independence Center (NIA P60 AG12583), a K24 mid-career development grant (K24 AG00930), an NIH training grant (T32 AG00219), and by a Special Emphasis Research Career Award (NIA K01 AG00657).

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: Recent studies indicate that abdominal fat accumulation, in particular intra-abdominal fat, is related to impaired endothelial function in young healthy volunteers. The aim of this study was to examine whether the distribution of body fat depots is related to impaired endothelial function in older men. METHODS: Cross-sectional sample of 38 older (68±1 y) sedentary (VO2max=2.4±0.1 l/min) men. Flow-mediated endothelial dependent vasodilation (EDD) was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Abdominal subcutaneous and visceral fat depots were assessed by computed tomography scan (CT-scan) at the L4-L5 region in the supine position. Percentage body fat was assessed via dual-energy X-ray absorptiometry (DEXA). RESULTS: Flow-mediated percentage change in brachial artery was 7.64±0.7%, suggesting an impaired flow-mediated EDD. Using simple linear regression analysis, there were no statistically significant relationship observed between flow-mediated EDD and the indices of total and abdominal adiposity (percentage body fat=29.3±0.9%, r= -0.11; total abdominal fat area=465±23 cm2, r= -0.1; intra-abdominal fat area=200±14 cm2, r= -0.14; subcutaneous fat area=265±13 cm2, r= -0.05; BMI=29.3±0.9 kg/m2, r= -0.07; and waist to hip ratio=0.98±0.01, r= -0.20). CONCLUSION: These findings suggest that in older sedentary men there is no clear correlation between adiposity and body fat distribution and impairment of flow-mediated endothelium dependent vasodilation.

AB - OBJECTIVE: Recent studies indicate that abdominal fat accumulation, in particular intra-abdominal fat, is related to impaired endothelial function in young healthy volunteers. The aim of this study was to examine whether the distribution of body fat depots is related to impaired endothelial function in older men. METHODS: Cross-sectional sample of 38 older (68±1 y) sedentary (VO2max=2.4±0.1 l/min) men. Flow-mediated endothelial dependent vasodilation (EDD) was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Abdominal subcutaneous and visceral fat depots were assessed by computed tomography scan (CT-scan) at the L4-L5 region in the supine position. Percentage body fat was assessed via dual-energy X-ray absorptiometry (DEXA). RESULTS: Flow-mediated percentage change in brachial artery was 7.64±0.7%, suggesting an impaired flow-mediated EDD. Using simple linear regression analysis, there were no statistically significant relationship observed between flow-mediated EDD and the indices of total and abdominal adiposity (percentage body fat=29.3±0.9%, r= -0.11; total abdominal fat area=465±23 cm2, r= -0.1; intra-abdominal fat area=200±14 cm2, r= -0.14; subcutaneous fat area=265±13 cm2, r= -0.05; BMI=29.3±0.9 kg/m2, r= -0.07; and waist to hip ratio=0.98±0.01, r= -0.20). CONCLUSION: These findings suggest that in older sedentary men there is no clear correlation between adiposity and body fat distribution and impairment of flow-mediated endothelium dependent vasodilation.

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Body fat distribution and flow-mediated endothelium-dependent vasodilation in older men

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