TY - JOUR
T1 - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx
T2 - Modeling odds ratios in pooled case-control data
AU - Lubin, Jay H.
AU - Gaudet, Mia M.
AU - Olshan, Andrew F.
AU - Kelsey, Karl
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Castellsague, Xavier
AU - Chen, Chu
AU - Curado, Maria Paula
AU - Maso, Luigino Dal
AU - Daudt, Alexander W.
AU - Fabianova, Eleonora
AU - Fernandez, Leticia
AU - Wünsch-Filho, Victor
AU - Franceschi, Silvia
AU - Herrero, Rolando
AU - Koifman, Sergio
AU - La Vecchia, Carlo
AU - Lazarus, Philip
AU - Levi, Fabio
AU - Lissowska, Jolanta
AU - Mates, Ioan Nicolae
AU - Matos, Elena
AU - McClean, Michael
AU - Menezes, Ana
AU - Morgenstern, Hal
AU - Muscat, Joshua
AU - Neto, Jose Eluf
AU - Purdue, Mark P.
AU - Rudnai, Peter
AU - Schwartz, Stephen M.
AU - Shangina, Oxana
AU - Sturgis, Erich M.
AU - Szeszenia-Dabrowska, Neonilia
AU - Talamini, Renato
AU - Wei, Qingyi
AU - Winn, Deborah
AU - Zhang, Zuo Feng
AU - Hashibe, Mia
AU - Hayes, Richard B.
PY - 2010
Y1 - 2010
N2 - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.
AB - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.
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U2 - 10.1093/aje/kwq088
DO - 10.1093/aje/kwq088
M3 - Article
C2 - 20494999
AN - SCOPUS:77953206251
SN - 0002-9262
VL - 171
SP - 1250
EP - 1261
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 12
ER -