Bombesin suppresses feeding in rats [10]

J. Gibbs; D. J. Fauser; E. A. Rowe; Barbara Jean Rolls; E. T. Rolls; S. P. Maddison

doi:10.1038/282208a0

Bombesin suppresses feeding in rats [10]

J. Gibbs, D. J. Fauser, E. A. Rowe, Barbara Jean Rolls, E. T. Rolls, S. P. Maddison

Research output: Contribution to journal › Letter › peer-review

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Abstract

Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin¹. BBS-like irnmunoactivity is widely distributed in mammalian gut^2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake^7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera^10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

Original language	English (US)
Pages (from-to)	208-210
Number of pages	3
Journal	Nature
Volume	282
Issue number	5735
DOIs	https://doi.org/10.1038/282208a0
State	Published - Dec 1 1979

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@article{52848802312840e9b6eac20d3f6ed550,

title = "Bombesin suppresses feeding in rats [10]",

abstract = "Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.",

author = "J. Gibbs and Fauser, {D. J.} and Rowe, {E. A.} and Rolls, {Barbara Jean} and Rolls, {E. T.} and Maddison, {S. P.}",

year = "1979",

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volume = "282",

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T1 - Bombesin suppresses feeding in rats [10]

AU - Gibbs, J.

AU - Fauser, D. J.

AU - Rowe, E. A.

AU - Rolls, Barbara Jean

AU - Rolls, E. T.

AU - Maddison, S. P.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

AB - Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

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DO - 10.1038/282208a0

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ER -

Bombesin suppresses feeding in rats [10]

Abstract

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