TY - JOUR
T1 - Bone-crack detection, targeting, and repair using ion gradients
AU - Yadav, Vinita
AU - Freedman, Jonathan D.
AU - Grinstaff, Mark
AU - Sen, Ayusman
PY - 2013/10/11
Y1 - 2013/10/11
N2 - Bone cracks can be detected by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a material with a high mineral content such as bone generates ion gradients, which can be utilized for active targeting and treatment. This approach to targeting a biological structure augments current methods, which are focused on biomacromolecular interactions involving proteins and nucleic acids.
AB - Bone cracks can be detected by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a material with a high mineral content such as bone generates ion gradients, which can be utilized for active targeting and treatment. This approach to targeting a biological structure augments current methods, which are focused on biomacromolecular interactions involving proteins and nucleic acids.
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U2 - 10.1002/anie.201305759
DO - 10.1002/anie.201305759
M3 - Article
C2 - 24039057
AN - SCOPUS:84885455489
SN - 1433-7851
VL - 52
SP - 10997
EP - 11001
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 42
ER -