Bone-crack detection, targeting, and repair using ion gradients

Vinita Yadav, Jonathan D. Freedman, Mark Grinstaff, Ayusman Sen

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Bone cracks can be detected by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a material with a high mineral content such as bone generates ion gradients, which can be utilized for active targeting and treatment. This approach to targeting a biological structure augments current methods, which are focused on biomacromolecular interactions involving proteins and nucleic acids.

Original languageEnglish (US)
Pages (from-to)10997-11001
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number42
StatePublished - Oct 11 2013

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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