Bordetella evolution: Lipid A and Toll-like receptor 4

Iain MacArthur, Paul B. Mann, Eric T. Harvill, Andrew Preston

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalJournal of Endotoxin Research
Issue number4
StatePublished - Aug 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases


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