Bordetella evolution: Lipid A and Toll-like receptor 4

Iain MacArthur; Paul B. Mann; Eric T. Harvill; Andrew Preston

doi:10.1177/0968051907082609

Bordetella evolution: Lipid A and Toll-like receptor 4

Iain MacArthur, Paul B. Mann, Eric T. Harvill, Andrew Preston

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Journal of Endotoxin Research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1177/0968051907082609
State	Published - Aug 2007

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0968051907082609

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abstract = "The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.",

author = "Iain MacArthur and Mann, {Paul B.} and Harvill, {Eric T.} and Andrew Preston",

year = "2007",

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AU - Mann, Paul B.

AU - Harvill, Eric T.

AU - Preston, Andrew

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AB - The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

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Bordetella evolution: Lipid A and Toll-like receptor 4

Abstract

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