Abstract
The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | Journal of Endotoxin Research |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2007 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Toxicology
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