Bovine cervical mucus penetration by human spermatozoa: Lack of association with conception

P. B. Marshburn, W. C. Dodson, A. F. Haney

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Penetration of bovine cervical mucus (BCMP) by human spermatozoa has been reported to be a test that may aid in assessment of male fertility. We determined the predictive value of BCMP for conception in 127 infertile couples. Fresh semen and swim-up specimens were tested with the Penetrak® assay. Out of 127 patients 16 (13% achieved pregnancy with 6 months to 2 years of follow-up. In the 62 men with sperm counts of >20 million/ml and motility of >60% 55 (89% had adequate BCMP while adequate penetration was found in only eight of 24 (33% with both sperm count and motility below these values (p < 0.001). A normal BCMP did not predict pregnancy, and a reduced BCMP had no prognostic value in designating couples not likely to conceive. The comparison of penetration values for semen following swim-up suggests that this preparation may improve the correlation of BCMP with fertility. These results indicate that the semen parameters of sperm density and percent motility predicted spermatozoal performance in the BCMP assay, and that the assessment of BCMP did not predict the likelihood of pregnancy.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalSystems Biology in Reproductive Medicine
Issue number1
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Urology


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