Brain localization of cholinergic influence on male sex behavior in rats: Agonists

Elaine M. Hull; Daniel Bitran; Elizabeth A. Pehek; Gregory M. Holmes; Robert K. Warner; Linda C. Band; Lynwood G. Clemens

doi:10.1016/0091-3057(88)90329-2

Brain localization of cholinergic influence on male sex behavior in rats: Agonists

Elaine M. Hull, Daniel Bitran, Elizabeth A. Pehek, Gregory M. Holmes, Robert K. Warner, Linda C. Band, Lynwood G. Clemens

Department of Neural and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cholinergic agonists were microinjected into either the lateral ventricle or the preoptic area of sexually experienced male rats. In Experiment 1 carbachol, injected into the lateral ventricles, delayed the initiation of sexual behavior. When injected into the preoptic area, carbachol again delayed the onset of copulation, but these delays were shorter than after ventricular injections. In addition, preoptic injections reduced the number of intromissions preceding ejaculation. In Experiment 2 ventricular injections of the muscarinic agonist oxotremorine again delayed initiation of sexual behavior and also slowed its rate. However, oxotremorine injections into the preoptic area, through cannulae angled to miss all ventricles, only decreased the number of intromissions preceding ejaculation. These data suggest that cholinergic synapses in proximity to the ventricles may decrease sexual arousal, while cholinergic mechanisms in or near the preoptic area may reduce ejaculatory threshold.

Original language	English (US)
Pages (from-to)	169-174
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(88)90329-2
State	Published - Sep 1988

All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(88)90329-2

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title = "Brain localization of cholinergic influence on male sex behavior in rats: Agonists",

abstract = "Cholinergic agonists were microinjected into either the lateral ventricle or the preoptic area of sexually experienced male rats. In Experiment 1 carbachol, injected into the lateral ventricles, delayed the initiation of sexual behavior. When injected into the preoptic area, carbachol again delayed the onset of copulation, but these delays were shorter than after ventricular injections. In addition, preoptic injections reduced the number of intromissions preceding ejaculation. In Experiment 2 ventricular injections of the muscarinic agonist oxotremorine again delayed initiation of sexual behavior and also slowed its rate. However, oxotremorine injections into the preoptic area, through cannulae angled to miss all ventricles, only decreased the number of intromissions preceding ejaculation. These data suggest that cholinergic synapses in proximity to the ventricles may decrease sexual arousal, while cholinergic mechanisms in or near the preoptic area may reduce ejaculatory threshold.",

author = "Hull, {Elaine M.} and Daniel Bitran and Pehek, {Elizabeth A.} and Holmes, {Gregory M.} and Warner, {Robert K.} and Band, {Linda C.} and Clemens, {Lynwood G.}",

note = "Funding Information: We wish to thank Dorothy Sideris for assistance with histology. This work was supported by NIMH grants MH4082601 and MH38526-01AI and BRSG grants 2S07RR0706619 and 2S07RR0706620 to E.M.H. and by a PHS award HD06760 to L.G.C.",

year = "1988",

month = sep,

doi = "10.1016/0091-3057(88)90329-2",

language = "English (US)",

volume = "31",

pages = "169--174",

journal = "Pharmacology, Biochemistry and Behavior",

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T1 - Brain localization of cholinergic influence on male sex behavior in rats

T2 - Agonists

AU - Hull, Elaine M.

AU - Bitran, Daniel

AU - Pehek, Elizabeth A.

AU - Holmes, Gregory M.

AU - Warner, Robert K.

AU - Band, Linda C.

AU - Clemens, Lynwood G.

N1 - Funding Information: We wish to thank Dorothy Sideris for assistance with histology. This work was supported by NIMH grants MH4082601 and MH38526-01AI and BRSG grants 2S07RR0706619 and 2S07RR0706620 to E.M.H. and by a PHS award HD06760 to L.G.C.

PY - 1988/9

Y1 - 1988/9

N2 - Cholinergic agonists were microinjected into either the lateral ventricle or the preoptic area of sexually experienced male rats. In Experiment 1 carbachol, injected into the lateral ventricles, delayed the initiation of sexual behavior. When injected into the preoptic area, carbachol again delayed the onset of copulation, but these delays were shorter than after ventricular injections. In addition, preoptic injections reduced the number of intromissions preceding ejaculation. In Experiment 2 ventricular injections of the muscarinic agonist oxotremorine again delayed initiation of sexual behavior and also slowed its rate. However, oxotremorine injections into the preoptic area, through cannulae angled to miss all ventricles, only decreased the number of intromissions preceding ejaculation. These data suggest that cholinergic synapses in proximity to the ventricles may decrease sexual arousal, while cholinergic mechanisms in or near the preoptic area may reduce ejaculatory threshold.

AB - Cholinergic agonists were microinjected into either the lateral ventricle or the preoptic area of sexually experienced male rats. In Experiment 1 carbachol, injected into the lateral ventricles, delayed the initiation of sexual behavior. When injected into the preoptic area, carbachol again delayed the onset of copulation, but these delays were shorter than after ventricular injections. In addition, preoptic injections reduced the number of intromissions preceding ejaculation. In Experiment 2 ventricular injections of the muscarinic agonist oxotremorine again delayed initiation of sexual behavior and also slowed its rate. However, oxotremorine injections into the preoptic area, through cannulae angled to miss all ventricles, only decreased the number of intromissions preceding ejaculation. These data suggest that cholinergic synapses in proximity to the ventricles may decrease sexual arousal, while cholinergic mechanisms in or near the preoptic area may reduce ejaculatory threshold.

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Brain localization of cholinergic influence on male sex behavior in rats: Agonists

Abstract

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