TY - JOUR
T1 - Brain spectrin
T2 - A review
AU - Goodman, Steven R.
AU - Zagon, Ian S.
N1 - Funding Information:
This work was suppurkd ht part by National Insthutes of Health Grants NS-19357s ad HL-26059t o S. R. Goodmau and NS-21246t o I. S. Zagou. S. R. Goodman is aa Established Rkvestigatoro f the American Heart &so&ion. We that& Patrick hfaese and huumtte Schwartz for the+ diligent worh in prc@ng the tnaeu&pt, and David Sittera ad PatriciaJ . McLaughgnf or B sss~cc. As~~~~~~S.~~~~e~ picture of the membraae skeletoa prestated in Fig. 1.
PY - 1984/12
Y1 - 1984/12
N2 - Red blood cell spectrin, along with actin and several other proteins, forms a skeletal meshwork on the cytoplasmic surface of the erythrocyte plasma membrane. This structure is thought to maintain red blood cell shape, membrane structural stability, and cellular elasticity, as well as controlling the lateral mobility of integral membrane proteins and the transbilayer movement of phospholipids. It is now clearly established that spectrin-related molecules are ubiquitous structural elements subjacent to the plasma membrane of mammalian and avian nonerythroid cells. In this review, we present the current knowledge concerning brain spectrin. Brain spectrin is an ~11S, ~1,000,000 molecular weight (αβ)2 tetramer containing subunits of 240,000 (α) and 235,000 (β) molecular weight. It is present in the cortical cytoplasm of all neuronal cell bodies and processes, and to a lesser extent in glial cells. Its involvement in the actin-membrane interaction, as well as other proposed functions in the nervous system is discussed.
AB - Red blood cell spectrin, along with actin and several other proteins, forms a skeletal meshwork on the cytoplasmic surface of the erythrocyte plasma membrane. This structure is thought to maintain red blood cell shape, membrane structural stability, and cellular elasticity, as well as controlling the lateral mobility of integral membrane proteins and the transbilayer movement of phospholipids. It is now clearly established that spectrin-related molecules are ubiquitous structural elements subjacent to the plasma membrane of mammalian and avian nonerythroid cells. In this review, we present the current knowledge concerning brain spectrin. Brain spectrin is an ~11S, ~1,000,000 molecular weight (αβ)2 tetramer containing subunits of 240,000 (α) and 235,000 (β) molecular weight. It is present in the cortical cytoplasm of all neuronal cell bodies and processes, and to a lesser extent in glial cells. Its involvement in the actin-membrane interaction, as well as other proposed functions in the nervous system is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0021671522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021671522&partnerID=8YFLogxK
U2 - 10.1016/0361-9230(84)90239-9
DO - 10.1016/0361-9230(84)90239-9
M3 - Article
C2 - 6099746
AN - SCOPUS:0021671522
SN - 0361-9230
VL - 13
SP - 813
EP - 832
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 6
ER -