Brave new proteins: What evolution reveals about protein structure

Annalisa Pastore; Arthur M. Lesk

doi:10.1016/0958-1669(91)90085-J

Brave new proteins: What evolution reveals about protein structure

Annalisa Pastore, Arthur M. Lesk

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Synthetic proteins provide important information about the principles of protein structure. They illuminate the processes of natural protein evaluation, but are not limited by these processes. Here, we review studies of several mutant proteins and discuss the general principles that can be derived from them.

Original language	English (US)
Pages (from-to)	592-598
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/0958-1669(91)90085-J
State	Published - Aug 1991

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/0958-1669(91)90085-J

Cite this

@article{98932873bc5e400bb53d36a729410aaf,

title = "Brave new proteins: What evolution reveals about protein structure",

abstract = "Synthetic proteins provide important information about the principles of protein structure. They illuminate the processes of natural protein evaluation, but are not limited by these processes. Here, we review studies of several mutant proteins and discuss the general principles that can be derived from them.",

author = "Annalisa Pastore and Lesk, {Arthur M.}",

note = "Funding Information: We both thank C Chothia and AG Murzin for helpful comments. AM Lesk also thanks the Kay Kendall Foundation for generous support.",

year = "1991",

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doi = "10.1016/0958-1669(91)90085-J",

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AU - Pastore, Annalisa

AU - Lesk, Arthur M.

N1 - Funding Information: We both thank C Chothia and AG Murzin for helpful comments. AM Lesk also thanks the Kay Kendall Foundation for generous support.

PY - 1991/8

Y1 - 1991/8

N2 - Synthetic proteins provide important information about the principles of protein structure. They illuminate the processes of natural protein evaluation, but are not limited by these processes. Here, we review studies of several mutant proteins and discuss the general principles that can be derived from them.

AB - Synthetic proteins provide important information about the principles of protein structure. They illuminate the processes of natural protein evaluation, but are not limited by these processes. Here, we review studies of several mutant proteins and discuss the general principles that can be derived from them.

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Brave new proteins: What evolution reveals about protein structure

Abstract

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