TY - JOUR
T1 - Brief access to sweets protect against relapse to cocaine-seeking
AU - Liu, Chuang
AU - Grigson, Patricia Sue
N1 - Funding Information:
The authors thank Anne E. Baldwin for editing a draft of the manuscript. This work was supported by PHS grants DA 09815 and DA 12473 from the National Institute on Drug Abuse (NIDA). We thank NIDA for generously providing the cocaine hydrochloride.
PY - 2005/7/5
Y1 - 2005/7/5
N2 - The availability of alternative rewards can reduce acquisition and maintenance of cocaine self-administration in rats and humans. Once acquired, however, addiction is an intractable disease where relapse is elicited by exposure to drug-associated cues, the drug itself, or stress. The present study shows that both cocaine-seeking and drug-induced relapse are significantly reduced when drug-experienced, but abstinent, rats are given just 5 min daily prior access to a palatable glucose + saccharin mixture. The results suggest that presentation of an alternative reward may be useful as a therapeutic intervention for cocaine seeking and relapse.
AB - The availability of alternative rewards can reduce acquisition and maintenance of cocaine self-administration in rats and humans. Once acquired, however, addiction is an intractable disease where relapse is elicited by exposure to drug-associated cues, the drug itself, or stress. The present study shows that both cocaine-seeking and drug-induced relapse are significantly reduced when drug-experienced, but abstinent, rats are given just 5 min daily prior access to a palatable glucose + saccharin mixture. The results suggest that presentation of an alternative reward may be useful as a therapeutic intervention for cocaine seeking and relapse.
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U2 - 10.1016/j.brainres.2005.05.013
DO - 10.1016/j.brainres.2005.05.013
M3 - Article
C2 - 15935999
AN - SCOPUS:20444432715
SN - 0006-8993
VL - 1049
SP - 128
EP - 131
JO - Brain research
JF - Brain research
IS - 1
ER -