Building an expanded bio-based economy through synthetic biology

Andrea M. Garza Elizondo; Ilenne del Valle Kessra; Erica Teixeira Prates; Evan Komp; Elise K. Phillips; Nandhini Ashok; Daniel A. Jacobson; Erin G. Webb; Yannick J. Bomble; William G. Alexander; Joanna Tannous; Chung Jui Tsai; Wayne A. Parrott; Xiaohan Yang; Breeanna R. Urbanowicz; Laura E. Bartley; Costas D. Maranas; Gerald A. Tuskan; Adam M. Guss; Carrie A. Eckert

doi:10.1016/j.biotechadv.2025.108775

Building an expanded bio-based economy through synthetic biology

Andrea M. Garza Elizondo
, Ilenne del Valle Kessra
, Erica Teixeira Prates
, Evan Komp
, Elise K. Phillips
, Nandhini Ashok
, Daniel A. Jacobson
, Erin G. Webb
, Yannick J. Bomble
, William G. Alexander
, Joanna Tannous
, Chung Jui Tsai
, Wayne A. Parrott
, Xiaohan Yang
, Breeanna R. Urbanowicz
, Laura E. Bartley
, Costas D. Maranas
, Gerald A. Tuskan
, Adam M. Guss
, Carrie A. Eckert

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The field of synthetic biology is essential to the continued development of a bio-based economy, creating mechanisms to supply carbon needed in the economy by both converting existing end-of-life wastes as well as by creating novel, purpose-grown and sustainable feedstocks. Here, we first discuss the near- and long-term resources available for use as feedstocks for bioconversion as well as the output molecules needed for building the foundation of an expanded bio-based economy. We then outline the organisms and phenotypic traits that are needed for the performance-advantaged chassis organisms of the future. Furthermore, we detail the advances, challenges, and opportunities in both microbial and plant synthetic biology relevant to expanding the bio-based economy. Finally, we explore technologies that have and will further enable advances in synthetic biology and the greater bio-based economy.

Original language	English (US)
Article number	108775
Journal	Biotechnology Advances
Volume	87
DOIs	https://doi.org/10.1016/j.biotechadv.2025.108775
State	Published - Mar 1 2026

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1016/j.biotechadv.2025.108775

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Garza Elizondo, A. M., del Valle Kessra, I., Prates, E. T., Komp, E., Phillips, E. K., Ashok, N., Jacobson, D. A., Webb, E. G., Bomble, Y. J., Alexander, W. G., Tannous, J., Tsai, C. J., Parrott, W. A., Yang, X., Urbanowicz, B. R., Bartley, L. E., Maranas, C. D., Tuskan, G. A., Guss, A. M., & Eckert, C. A. (2026). Building an expanded bio-based economy through synthetic biology. Biotechnology Advances, 87, Article 108775. https://doi.org/10.1016/j.biotechadv.2025.108775

@article{0116af05fba74d658df30f1967a0c438,

title = "Building an expanded bio-based economy through synthetic biology",

abstract = "The field of synthetic biology is essential to the continued development of a bio-based economy, creating mechanisms to supply carbon needed in the economy by both converting existing end-of-life wastes as well as by creating novel, purpose-grown and sustainable feedstocks. Here, we first discuss the near- and long-term resources available for use as feedstocks for bioconversion as well as the output molecules needed for building the foundation of an expanded bio-based economy. We then outline the organisms and phenotypic traits that are needed for the performance-advantaged chassis organisms of the future. Furthermore, we detail the advances, challenges, and opportunities in both microbial and plant synthetic biology relevant to expanding the bio-based economy. Finally, we explore technologies that have and will further enable advances in synthetic biology and the greater bio-based economy.",

author = "\{Garza Elizondo\}, \{Andrea M.\} and \{del Valle Kessra\}, Ilenne and Prates, \{Erica Teixeira\} and Evan Komp and Phillips, \{Elise K.\} and Nandhini Ashok and Jacobson, \{Daniel A.\} and Webb, \{Erin G.\} and Bomble, \{Yannick J.\} and Alexander, \{William G.\} and Joanna Tannous and Tsai, \{Chung Jui\} and Parrott, \{Wayne A.\} and Xiaohan Yang and Urbanowicz, \{Breeanna R.\} and Bartley, \{Laura E.\} and Maranas, \{Costas D.\} and Tuskan, \{Gerald A.\} and Guss, \{Adam M.\} and Eckert, \{Carrie A.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2025. Published by Elsevier Inc.",

year = "2026",

month = mar,

day = "1",

doi = "10.1016/j.biotechadv.2025.108775",

language = "English (US)",

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journal = "Biotechnology Advances",

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Garza Elizondo, AM, del Valle Kessra, I, Prates, ET, Komp, E, Phillips, EK, Ashok, N, Jacobson, DA, Webb, EG, Bomble, YJ, Alexander, WG, Tannous, J, Tsai, CJ, Parrott, WA, Yang, X, Urbanowicz, BR, Bartley, LE, Maranas, CD, Tuskan, GA, Guss, AM & Eckert, CA 2026, 'Building an expanded bio-based economy through synthetic biology', Biotechnology Advances, vol. 87, 108775. https://doi.org/10.1016/j.biotechadv.2025.108775

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AU - Prates, Erica Teixeira

AU - Komp, Evan

AU - Phillips, Elise K.

AU - Ashok, Nandhini

AU - Jacobson, Daniel A.

AU - Webb, Erin G.

AU - Bomble, Yannick J.

AU - Alexander, William G.

AU - Tannous, Joanna

AU - Tsai, Chung Jui

AU - Parrott, Wayne A.

AU - Yang, Xiaohan

AU - Urbanowicz, Breeanna R.

AU - Bartley, Laura E.

AU - Maranas, Costas D.

AU - Tuskan, Gerald A.

AU - Guss, Adam M.

AU - Eckert, Carrie A.

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AB - The field of synthetic biology is essential to the continued development of a bio-based economy, creating mechanisms to supply carbon needed in the economy by both converting existing end-of-life wastes as well as by creating novel, purpose-grown and sustainable feedstocks. Here, we first discuss the near- and long-term resources available for use as feedstocks for bioconversion as well as the output molecules needed for building the foundation of an expanded bio-based economy. We then outline the organisms and phenotypic traits that are needed for the performance-advantaged chassis organisms of the future. Furthermore, we detail the advances, challenges, and opportunities in both microbial and plant synthetic biology relevant to expanding the bio-based economy. Finally, we explore technologies that have and will further enable advances in synthetic biology and the greater bio-based economy.

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VL - 87

JO - Biotechnology Advances

JF - Biotechnology Advances

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Building an expanded bio-based economy through synthetic biology

Abstract

All Science Journal Classification (ASJC) codes

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