TY - JOUR
T1 - Bystander Selection for Antimicrobial Resistance
T2 - Implications for Patient Health
AU - Morley, Valerie J.
AU - Woods, Robert J.
AU - Read, Andrew F.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/10
Y1 - 2019/10
N2 - Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.
AB - Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.
UR - http://www.scopus.com/inward/record.url?scp=85068442497&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068442497&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2019.06.004
DO - 10.1016/j.tim.2019.06.004
M3 - Review article
C2 - 31288975
AN - SCOPUS:85068442497
SN - 0966-842X
VL - 27
SP - 864
EP - 877
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 10
ER -
