Bystander Selection for Antimicrobial Resistance: Implications for Patient Health

Valerie J. Morley; Robert J. Woods; Andrew F. Read

doi:10.1016/j.tim.2019.06.004

Bystander Selection for Antimicrobial Resistance: Implications for Patient Health

Valerie J. Morley
, Robert J. Woods
, Andrew F. Read

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.

Original language	English (US)
Pages (from-to)	864-877
Number of pages	14
Journal	Trends in Microbiology
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/j.tim.2019.06.004
State	Published - Oct 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

Access to Document

10.1016/j.tim.2019.06.004

Cite this

@article{d8b340a8c0394474abc829dba9c93cda,

title = "Bystander Selection for Antimicrobial Resistance: Implications for Patient Health",

abstract = "Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.",

author = "Morley, \{Valerie J.\} and Woods, \{Robert J.\} and Read, \{Andrew F.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = oct,

doi = "10.1016/j.tim.2019.06.004",

language = "English (US)",

volume = "27",

pages = "864--877",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Bystander Selection for Antimicrobial Resistance

T2 - Implications for Patient Health

AU - Morley, Valerie J.

AU - Woods, Robert J.

AU - Read, Andrew F.

PY - 2019/10

Y1 - 2019/10

N2 - Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.

AB - Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens.

UR - https://www.scopus.com/pages/publications/85068442497

UR - https://www.scopus.com/pages/publications/85068442497#tab=citedBy

U2 - 10.1016/j.tim.2019.06.004

DO - 10.1016/j.tim.2019.06.004

M3 - Review article

C2 - 31288975

AN - SCOPUS:85068442497

SN - 0966-842X

VL - 27

SP - 864

EP - 877

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 10

ER -

Bystander Selection for Antimicrobial Resistance: Implications for Patient Health

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this