Cadaveric small bowel and small bowel-liver transplantation in humans

Satoru Todo, Andreas G. Tzakis, Kareem Abu-Elmagd, Jorge Reyes, John J. Fung, Adrian Casavilla, Kenjiro Nakamura, Atsuhito Yagihashi, Ashok Jain, Noriko Murase, Yuichi Iwaki, Anthony J. Demetris, David Van Thiel, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

153 Scopus citations


Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults. The five patients are living 2-13 months posttransplantation with complete alimentation by the intestine. The typical postoperative course was stormy, with sluggish resumption of gastrointestinal function. The patient with small intestinal transplantation alone had the most difficult course of the five, including two severe rejections, bacterial and fungal translocation with bacteremia, renal failure with the rejections, and permanent consignment to renal dialysis. The first four patients (studies on the fifth were incomplete) had replacement of the lymphor-eticular cells in the graft lamina propria by their own lymphoreticular cells. Although the surgical and aftercare of these patients was difficult, the eventual uniform success suggests that intestinal transplantation has moved toward becoming a practical clinical service.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
Issue number2
StatePublished - Feb 1992

All Science Journal Classification (ASJC) codes

  • Transplantation


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