Caffeine pharmacokinetics in preterm infants older than 2 weeks

S. A. Pearlman; S. C. Duran; M. A. Wood; M. J. Maisels; C. M. Berlin

doi:10.1159/000480966

Caffeine pharmacokinetics in preterm infants older than 2 weeks

S. A. Pearlman, S. C. Duran, M. A. Wood, M. J. Maisels, C. M. Berlin

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Abstract

We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 ± 1.9 weeks (mean ± SD) and they were studied at 20.7 ± 6.6 days (mean ± SD) postnatal age. The caffeine half-life was 52.03 ± 23.87 h (mean ± SD) and the theophylline half-life was 77.04 ± 65.01 h (mean ± SD).

Original language	English (US)
Pages (from-to)	65-69
Number of pages	5
Journal	Developmental Pharmacology and Therapeutics
Volume	12
Issue number	2
DOIs	https://doi.org/10.1159/000480966
State	Published - 1989

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

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abstract = "We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 ± 1.9 weeks (mean ± SD) and they were studied at 20.7 ± 6.6 days (mean ± SD) postnatal age. The caffeine half-life was 52.03 ± 23.87 h (mean ± SD) and the theophylline half-life was 77.04 ± 65.01 h (mean ± SD).",

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AU - Maisels, M. J.

AU - Berlin, C. M.

PY - 1989

Y1 - 1989

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Caffeine pharmacokinetics in preterm infants older than 2 weeks

Abstract

All Science Journal Classification (ASJC) codes

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