Caffeine pharmacokinetics in preterm infants older than 2 weeks

S. A. Pearlman, S. C. Duran, M. A. Wood, M. J. Maisels, C. M. Berlin

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 ± 1.9 weeks (mean ± SD) and they were studied at 20.7 ± 6.6 days (mean ± SD) postnatal age. The caffeine half-life was 52.03 ± 23.87 h (mean ± SD) and the theophylline half-life was 77.04 ± 65.01 h (mean ± SD).

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalDevelopmental Pharmacology and Therapeutics
Issue number2
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)


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