Calcium-Blocker Therapy for Unstable Angina Pectoris

Robert Zelis

Research output: Contribution to journalEditorialpeer-review

29 Scopus citations


Now that the calcium blockers are available, how does this change the modern management of angina pectoris? Although there are relatively unusual causes of angina, such as hypertrophic cardiomyopathy and aortic stenosis, the vast majority of these patients have fixed atherosclerotic coronary-artery disease, and pain occurs when myocardial oxygen requirements increase. This pathophysiologic process gives rise to the syndrome of chronic stable exertional angina. Current therapy consists of nitrates and beta-adrenergic-receptor blocking agents to decrease myocardial oxygen consumption, with coronary-bypass surgery for patients at high risk of myocardial infarction or those unresponsive to medical therapy. A few patients have a. . .

Original languageEnglish (US)
Pages (from-to)926-928
Number of pages3
JournalNew England Journal of Medicine
Issue number15
StatePublished - Apr 15 1982

All Science Journal Classification (ASJC) codes

  • General Medicine


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