TY - JOUR
T1 - Calcium conductance-dependent network synchronization is differentially modulated by firing frequency
AU - Lu, Meili
AU - Qin, Yingmei
AU - Li, Huiyan
AU - Che, Yanqiu
AU - Han, Chunxiao
AU - Wei, Xile
N1 - Funding Information:
This work is supported by the National Natural Science Foundation of China (Grant Nos. 61501330 and 61771330), the Tianjin Municipal Special Program of Talents Development for Excellent Youth Scholars and the Natural Science Foundation of Tianjin (Grant Nos. 17JCQNJC03700 and 18JCYBJC88200).
Publisher Copyright:
© 2019 World Scientific Publishing Company.
PY - 2019/6/20
Y1 - 2019/6/20
N2 - Synchronous oscillations in certain frequencies of the sub-thalamic nucleus (STN) neurons are closely related to the physical symptoms of Parkinson's disease (PD). Recent results have highlighted the importance of calcium channels in the synchronization properties and regulation of STN neurons. In this paper, a novel hybrid neuron model which can capture the electrophysiological signature of neurons with low or high density of calcium channels is used to explore the synchronization propensity and regulation by firing frequencies of neurons. Numerical simulations show that the synchronization propensity of networks consisting of the novel hybrid neurons is quite distinguishing in low and high calcium conductance modes, especially, the synchronization can be differentially modulated by network frequencies in the two modes. By analyzing the firing frequency and phase response curve of the individual neuron, we find that a single parameter of the hybrid neuron, which is a direct image of the calcium conductance, is crucial in determining the excitability and response properties of the neuron. Different phase response properties of single neurons in different calcium conductance modes lead to network synchronization discrepancies.
AB - Synchronous oscillations in certain frequencies of the sub-thalamic nucleus (STN) neurons are closely related to the physical symptoms of Parkinson's disease (PD). Recent results have highlighted the importance of calcium channels in the synchronization properties and regulation of STN neurons. In this paper, a novel hybrid neuron model which can capture the electrophysiological signature of neurons with low or high density of calcium channels is used to explore the synchronization propensity and regulation by firing frequencies of neurons. Numerical simulations show that the synchronization propensity of networks consisting of the novel hybrid neurons is quite distinguishing in low and high calcium conductance modes, especially, the synchronization can be differentially modulated by network frequencies in the two modes. By analyzing the firing frequency and phase response curve of the individual neuron, we find that a single parameter of the hybrid neuron, which is a direct image of the calcium conductance, is crucial in determining the excitability and response properties of the neuron. Different phase response properties of single neurons in different calcium conductance modes lead to network synchronization discrepancies.
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U2 - 10.1142/S0217979219501601
DO - 10.1142/S0217979219501601
M3 - Article
AN - SCOPUS:85067969841
SN - 0217-9792
VL - 33
JO - International Journal of Modern Physics B
JF - International Journal of Modern Physics B
IS - 15
M1 - 1950160
ER -