TY - JOUR
T1 - Calcium dependent protein kinases (CDPKS)
T2 - Key to malaria eradication
AU - Kadian, Kavita
AU - Gupta, Yash
AU - Kempaiah, Prakasha
AU - Gupta, Nikesh
AU - Sharma, Arun
AU - Rawat, Manmeet
N1 - Funding Information:
NG is highly thankful to Dr. D.S. Kothari Post-Doctoral Fellowship Cell, University Grants Commission (UGC), India, for financial assistance
Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017
Y1 - 2017
N2 - Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.
AB - Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.
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U2 - 10.2174/1568026617666170130112714
DO - 10.2174/1568026617666170130112714
M3 - Review article
C2 - 28137235
AN - SCOPUS:85021180099
SN - 1568-0266
VL - 17
SP - 2215
EP - 2220
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 19
ER -