Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells

Mark Kester; Yasser Heakal; Todd Fox; Arati Sharma; Gavin P. Robertson; Thomas T. Morgan; Erhan I. Altinoǧlu; Amra Tabaković; Mylisa R. Parette; Sarah M. Rouse; Victor Ruiz-Velasco; James H. Adair

doi:10.1021/nl802098g

Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells

Mark Kester, Yasser Heakal, Todd Fox, Arati Sharma, Gavin P. Robertson, Thomas T. Morgan, Erhan I. Altinoǧlu, Amra Tabaković, Mylisa R. Parette, Sarah M. Rouse, Victor Ruiz-Velasco, James H. Adair

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 °C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

Original language	English (US)
Pages (from-to)	4116-4121
Number of pages	6
Journal	Nano letters
Volume	8
Issue number	12
DOIs	https://doi.org/10.1021/nl802098g
State	Published - Dec 2008

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl802098g

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Kester, M., Heakal, Y., Fox, T., Sharma, A., Robertson, G. P., Morgan, T. T., Altinoǧlu, E. I., Tabaković, A., Parette, M. R., Rouse, S. M., Ruiz-Velasco, V., & Adair, J. H. (2008). Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells. Nano letters, 8(12), 4116-4121. https://doi.org/10.1021/nl802098g

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title = "Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells",

abstract = "Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 °C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.",

author = "Mark Kester and Yasser Heakal and Todd Fox and Arati Sharma and Robertson, {Gavin P.} and Morgan, {Thomas T.} and Altinoǧlu, {Erhan I.} and Amra Tabakovi{\'c} and Parette, {Mylisa R.} and Rouse, {Sarah M.} and Victor Ruiz-Velasco and Adair, {James H.}",

year = "2008",

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doi = "10.1021/nl802098g",

language = "English (US)",

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T1 - Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells

AU - Kester, Mark

AU - Heakal, Yasser

AU - Fox, Todd

AU - Sharma, Arati

AU - Robertson, Gavin P.

AU - Morgan, Thomas T.

AU - Altinoǧlu, Erhan I.

AU - Tabaković, Amra

AU - Parette, Mylisa R.

AU - Rouse, Sarah M.

AU - Ruiz-Velasco, Victor

AU - Adair, James H.

PY - 2008/12

Y1 - 2008/12

N2 - Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 °C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

AB - Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 °C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

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JO - Nano letters

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Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer Cells

Abstract

All Science Journal Classification (ASJC) codes

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