Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

Salvatore Mancarella, Youjun Wang, Donald L. Gill

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations


Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

Original languageEnglish (US)
Pages (from-to)R950-R952
JournalCurrent Biology
Issue number20
StatePublished - Nov 3 2009

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


Dive into the research topics of 'Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations'. Together they form a unique fingerprint.

Cite this