Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

Salvatore Mancarella; Youjun Wang; Donald L. Gill

doi:10.1016/j.cub.2009.08.051

Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

Salvatore Mancarella, Youjun Wang, Donald L. Gill

Department of Cellular and Molecular Physiology

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Receptor-induced Ca²⁺ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca²⁺ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca²⁺ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

Original language	English (US)
Pages (from-to)	R950-R952
Journal	Current Biology
Volume	19
Issue number	20
DOIs	https://doi.org/10.1016/j.cub.2009.08.051
State	Published - Nov 3 2009

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2009.08.051

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title = "Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations",

abstract = "Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.",

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T2 - STIM Dynamics Mediate Spatially Unique Oscillations

AU - Mancarella, Salvatore

AU - Wang, Youjun

AU - Gill, Donald L.

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Y1 - 2009/11/3

N2 - Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

AB - Receptor-induced Ca2+ oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca2+ levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca2+ entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.

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ER -

Calcium Signals: STIM Dynamics Mediate Spatially Unique Oscillations

Abstract

All Science Journal Classification (ASJC) codes

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