Calcium Supplementation and Bone Mineral Density in Adolescent Girls

Tom Lloyd, Mark B. Andon, Nan Rollings, Juliann K. Martel, J. Richard Landis, Laurence M. Demers, Douglas F. Eggli, Kessey Kieselhorst, Howard E. Kulin

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438 Scopus citations


To evaluate the effect of calcium supplementation on bone acquisition in adolescent white girls. A randomized, double-blind, placebo-controlled trial of the effect of 18 months of calcium supplementation on bone density and bone mass. Ninety-four girls with a mean age of 11.9+0.5 years at study entry. University hospital in a small town. Calcium supplementation, 500 mg/d calcium as calcium citrate malate; controls received placebo pills. Bone mineral density and bone mineral content of the lumbar spine and total body were measured by dual-energy x-ray absorptiometry and calcium excretion from 24-hour urine specimens. Calcium intake from dietary sources averaged 960 mg/d for the entire study group. The supplemented group received, on average, an additional 354 mg/d of calcium. The supplemented group compared with the placebo group had greater increases of lumbar spine bone density (18.7% vs 15.8%; P=.03), lumbar spine bone mineral content (39.4% vs 34.7%; P=.06), total body bone mineral density (9.6% vs 8.3%; P=.05), and 24-hour urinary calcium excretion (90.4 vs 72.9 mg/d; P=.02), respectively. Increasing daily calcium intake from 80% of the recommended daily allowance to 110% via supplementation with calcium citrate malate resulted in significant increases in total body and spinal bone density in adolescent girls. The increase of 24 g of bone gain per year among the supplemented group translates to an additional 1.3% skeletal mass per year during adolescent growth, which may provide protection against future osteoporotic fracture.

Original languageEnglish (US)
Pages (from-to)841-844
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number7
StatePublished - Aug 18 1993

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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