Abstract
We calibrate a mathematical model of renal tubulointerstitial fibrosis by Hao et al which is used to explore potential drugs for Lupus Nephritis, against a real data set of 84 patients. For this purpose, we present a general calibration procedure which can be used for the calibration analysis of other biological systems as well. Central to the procedure is the idea of designing a Bayesian Gaussian process (GP) emulator that can be used as a surrogate of the fibrosis mathematical model which is computationally expensive to run massively at every input value. The procedure relies on detecting influential model parameters by a GP-based sensitivity analysis, and calibrating them by specifying a maximum likelihood criterion, tailored to the application, which is optimized via Bayesian global optimization.
Original language | English (US) |
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Article number | e3329 |
Journal | International Journal for Numerical Methods in Biomedical Engineering |
Volume | 36 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2020 |
All Science Journal Classification (ASJC) codes
- Software
- Biomedical Engineering
- Modeling and Simulation
- Molecular Biology
- Computational Theory and Mathematics
- Applied Mathematics