TY - JOUR
T1 - Can Ischemia-modified albumin be used as an objective biomarker for renal ischemic damage? An experimental study with wistar albino rats
AU - Kocan, H.
AU - Citgez, S.
AU - Yucetas, U.
AU - Yucetas, E.
AU - Yazici, M.
AU - Amasyali, A. S.
AU - Unluer, E.
AU - Tasci, A. I.
PY - 2014
Y1 - 2014
N2 - Introduction. This study sought to evaluate the correlation of ischemia-modified albumin (IMA) with time-dependent renal ischemic injury. Methods. We established 5 groups of 8 Wistar albino rats as follows: sham, 10 minutes of renal ischemia, 20 minutes of renal ischemia, 30 minutes of renal ischemia, and 40 minutes of renal ischemia. Renal ischemia was established by occlusion of the right renal pedicle. Blood samples were obtained after exploration of the renal pedicle in the sham group and after thoracotomy and directly from the cardiac chambers at the end of the ischemic period in the other groups. The ischemic kidneys were removed for histopathological evaluation, and the rats were killed. Results. There were significant differences among the IMA levels of the 5 groups (P= .0013). Pathological examination showed that renal ischemic injury corresponded to the duration of ischemia. In the group analysis, the pathological evaluation scores were significantly different among the groups (P < .001). Conclusions. This study shows that IMA levels can be used as a nonselective biomarker for renal ischemic injury. However, further studies are needed to support our findings.
AB - Introduction. This study sought to evaluate the correlation of ischemia-modified albumin (IMA) with time-dependent renal ischemic injury. Methods. We established 5 groups of 8 Wistar albino rats as follows: sham, 10 minutes of renal ischemia, 20 minutes of renal ischemia, 30 minutes of renal ischemia, and 40 minutes of renal ischemia. Renal ischemia was established by occlusion of the right renal pedicle. Blood samples were obtained after exploration of the renal pedicle in the sham group and after thoracotomy and directly from the cardiac chambers at the end of the ischemic period in the other groups. The ischemic kidneys were removed for histopathological evaluation, and the rats were killed. Results. There were significant differences among the IMA levels of the 5 groups (P= .0013). Pathological examination showed that renal ischemic injury corresponded to the duration of ischemia. In the group analysis, the pathological evaluation scores were significantly different among the groups (P < .001). Conclusions. This study shows that IMA levels can be used as a nonselective biomarker for renal ischemic injury. However, further studies are needed to support our findings.
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U2 - 10.1016/j.transproceed.2014.11.001
DO - 10.1016/j.transproceed.2014.11.001
M3 - Article
C2 - 25498045
AN - SCOPUS:84926287642
SN - 0041-1345
VL - 46
SP - 3326
EP - 3329
JO - Transplantation proceedings
JF - Transplantation proceedings
IS - 10
ER -