Cancer and Parkinson's disease: The odd couple

Xiang Gao, Y. Ning

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Epidemiological studies have consistently shown that individuals with Parkinson's disease (PD) are less likely to develop nonmelanoma cancers and vice versa. In contrast, the co-occurrence of PD and melanoma has been reported in numerous studies. The exact mechanisms underlying the observed cancer - PD association are not clear. Different hypotheses have been put forward, including shared environmental/lifestyle factors (e.g., smoking and socioeconomic status) and common genetic components (e.g., parkinson protein 2 [PARK2], leucine-rich repeat kinase 2 [LRRK2], Parkinson disease [autosomal recessive, early onset] 7 [PARK7, DJ-1] and pigmentation genes). In the current review, we summarize recent findings to offer new insight into the pathogenesis of both conditions.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalDrugs of Today
Issue number3
StatePublished - Mar 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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