Capillary electrophoresis of single mammalian cells

Lori A. Woods, Thomas P. Roddy, Andrew G. Ewing

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Capillary electrophoresis (CE) has been established as powerful tool for single cell analysis. Newly developed sampling, separation and detection methods have allowed the investigation of single mammalian cells with CE despite their small size and complex composition. Advances in sample injection techniques include several novel methods for the injection of whole cells and sampling techniques for the study of cellular secretion. CE of single mammalian cells has been applied in a wide range of fields including protein analysis, neuroscience, and oncology. The development of new detection schemes in the analysis of single mammalian cells with CE has included studies of protein expression and the utilization of mass spectrometric and electrochemical detection. Subcellular mammalian cell analysis with CE also has been investigated.

Original languageEnglish (US)
Pages (from-to)1181-1187
Number of pages7
Issue number9
StatePublished - May 2004

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry


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