Capsaicin suppresses phorbol ester-induced activation of NF-κB/Rel and AP-1 transcription factors in mouse epidermis

Seong Su Han, Young Sam Keum, Hyo Joung Seo, Kyung Soo Chun, Sang Sup Lee, Young Joon Surh

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

Capsaicin, the principal pungent ingredient of hot chili peppers, has anti-inflammatory and analgesic properties and is currently used as a topical cream for the management of various neuropathic conditions. In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-κB via blockade of IκB-α degradation with subsequent inhibition of nuclear translocation of the functionally active NF-κB subunit, p65. Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment. Since altered transactivation of NF-κB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalCancer Letters
Volume164
Issue number2
DOIs
StatePublished - Mar 26 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Capsaicin suppresses phorbol ester-induced activation of NF-κB/Rel and AP-1 transcription factors in mouse epidermis'. Together they form a unique fingerprint.

Cite this