Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21

Marie M. Gleason; James S. Roloff; Stephen E. Cyran; Howard S. Weber; Barry G. Baylen; John L. Myers

doi:10.1007/BF00795376

Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21

Marie M. Gleason, James S. Roloff, Stephen E. Cyran, Howard S. Weber, Barry G. Baylen, John L. Myers

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5 Scopus citations

Abstract

Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients, with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and thus warrant close evaluation while on such medications.

Original language	English (US)
Pages (from-to)	227-229
Number of pages	3
Journal	Pediatric cardiology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/BF00795376
State	Published - Oct 1993

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1007/BF00795376

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abstract = "Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients, with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is {"}at risk{"} for suppression, and thus warrant close evaluation while on such medications.",

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AU - Gleason, Marie M.

AU - Roloff, James S.

AU - Cyran, Stephen E.

AU - Weber, Howard S.

AU - Baylen, Barry G.

AU - Myers, John L.

PY - 1993/10

Y1 - 1993/10

N2 - Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients, with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and thus warrant close evaluation while on such medications.

AB - Neutropenia is an infrequent complication following administration of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most reports have been in adult patients, with rare reports in the pediatric population. We report two cases of neutropenia following captopril use in cardiac patients, with trisomy 21. As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and thus warrant close evaluation while on such medications.

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ER -

Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21

Abstract

All Science Journal Classification (ASJC) codes

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