Carbohydrate Metabolism in the Central Nervous System

Ian Simpson, S. J. Vannucci

Research output: Chapter in Book/Report/Conference proceedingChapter


Glucose is central to the energy metabolism of most mammalian cells and it is the primary and obligate fuel for the mammalian brain. Cerebral glucose metabolism is predominantly aerobic, necessitating a continual and high level of oxygen delivery. Unlike peripheral tissues such as heart and muscle, the brain is unable to access other energetic fuels, that is, circulating fatty acids and triglycerides, due to the restricted movement of these compounds across the blood-brain barrier. This article will present a review of cerebral glucose metabolism and the limitations and demands specific to the mammalian brain.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
StatePublished - Feb 15 2013

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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