Carbohydrate Metabolism in the Central Nervous System

Ian Simpson, S. J. Vannucci

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Glucose is central to the energy metabolism of most mammalian cells and it is the primary and obligate fuel for the mammalian brain. Cerebral glucose metabolism is predominantly aerobic, necessitating a continual and high level of oxygen delivery. Unlike peripheral tissues such as heart and muscle, the brain is unable to access other energetic fuels, that is, circulating fatty acids and triglycerides, due to the restricted movement of these compounds across the blood-brain barrier. This article will present a review of cerebral glucose metabolism and the limitations and demands specific to the mammalian brain.

    Original languageEnglish (US)
    Title of host publicationEncyclopedia of Biological Chemistry
    Subtitle of host publicationSecond Edition
    PublisherElsevier Inc.
    Pages368-373
    Number of pages6
    ISBN (Electronic)9780123786319
    ISBN (Print)9780123786302
    DOIs
    StatePublished - Feb 15 2013

    All Science Journal Classification (ASJC) codes

    • General Biochemistry, Genetics and Molecular Biology

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