Carbovir-related compounds and phosphonate analogues

Phuong T. Pham; Robert Vince

doi:10.1080/10426500601047578

Carbovir-related compounds and phosphonate analogues

Phuong T. Pham, Robert Vince

Penn State Scranton

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.

Original language	English (US)
Pages (from-to)	779-791
Number of pages	13
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	182
Issue number	4
DOIs	https://doi.org/10.1080/10426500601047578
State	Published - Apr 2007

All Science Journal Classification (ASJC) codes

Biochemistry
Organic Chemistry
Inorganic Chemistry

Access to Document

10.1080/10426500601047578

Cite this

@article{57cdc7d75de946448f123eae91863aac,

title = "Carbovir-related compounds and phosphonate analogues",

abstract = "Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.",

author = "Pham, \{Phuong T.\} and Robert Vince",

year = "2007",

month = apr,

doi = "10.1080/10426500601047578",

language = "English (US)",

volume = "182",

pages = "779--791",

journal = "Phosphorus, Sulfur and Silicon and the Related Elements",

issn = "1042-6507",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Carbovir-related compounds and phosphonate analogues

AU - Pham, Phuong T.

AU - Vince, Robert

PY - 2007/4

Y1 - 2007/4

N2 - Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.

AB - Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3- cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at -78°C rather than at the reported1 ambient temperature, where only the less ring-strained and more stable γ-lactam is formed.

UR - https://www.scopus.com/pages/publications/33847378452

UR - https://www.scopus.com/inward/citedby.url?scp=33847378452&partnerID=8YFLogxK

U2 - 10.1080/10426500601047578

DO - 10.1080/10426500601047578

M3 - Article

AN - SCOPUS:33847378452

SN - 1042-6507

VL - 182

SP - 779

EP - 791

JO - Phosphorus, Sulfur and Silicon and the Related Elements

JF - Phosphorus, Sulfur and Silicon and the Related Elements

IS - 4

ER -

Carbovir-related compounds and phosphonate analogues

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this