Cardiac amyloidosis-A review of current literature for the practicing physician

Samantha Ash, Eran Shorer, Devyani Ramgobin, Maique Vo, Jonathan Gibbons, Reshma Golamari, Rahul Jain, Rohit Jain

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The amyloidoses are a family of diseases in which misfolded precursor proteins aggregate to form amyloid and deposit in body tissues. A very serious yet underrecognized form of this disease is cardiac amyloidosis, in which amyloid deposits into the extracellular space of the myocardium, resulting in thickening and stiffening of ventricular walls with resultant heart failure and conductive dysfunction. This review provides a discussion of the pathogenesis and clinical presentation of cardiac amyloidosis subtypes, as well as an up-to-date approach to diagnosis and treatment. Significant progress has been made in recent years regarding diagnosis and treatment of this condition, but prognosis remains heavily reliant on early detection of the disease. Two types of precursor protein are responsible for most cardiac amyloidosis cases: transthyretin amyloid, and immunoglobulin-derived light chain amyloid. An early diagnosis of cardiac amyloidosis can allow for novel treatment modalities to be initiated with the potential to improve prognosis.

Original languageEnglish (US)
Pages (from-to)322-331
Number of pages10
JournalClinical Cardiology
Issue number3
StatePublished - Mar 2021

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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