Cardiac Arrhythmias Associated with Disopyramide

Evlin L. Kinney, Elizabeth H. Field, Michael P. Salmon, Robert Zelis

Research output: Contribution to journalLetterpeer-review

9 Scopus citations


To the Editor: Rare adverse effects of new drugs are often missed in prospective trials.* Disopyramide (Norpace) has been on the United States market since 1977 and began to be used at this medical center in 1978. Shortly thereafter, we suspected that disopyramide might occasionally induce dysrhythmias. We therefore retrospectively reviewed the first 50 disopyramide-treated inpatients at our hospital. In all but one patient (Case 3), disopyramide had been given to suppress premature ventricular contractions. Case 1 was a 67-year-old man with coronary-artery disease and marked left ventricular dilatation, who was admitted with quinidine-induced thrombocytopenia. Disopyramide, 300 mg by mouth. . .

Original languageEnglish (US)
Pages (from-to)1146
Number of pages1
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 15 1980

All Science Journal Classification (ASJC) codes

  • General Medicine


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