TY - JOUR
T1 - Cardiac mechanics are impaired during fatiguing exercise and cold pressor test in healthy older adults
AU - Muller, Matthew D.
AU - Mast, Jessica L.
AU - Patel, Hardikkumar
AU - Sinoway, Lawrence I.
PY - 2013/1/15
Y1 - 2013/1/15
N2 - The use of TDI to quantify LV systolic and diastolic function is becoming more popular in clinical care as well as in physiological experiments. Our data indicate that Sm and Em are reduced in healthy older adults during IFHG and CPT. Furthermore, greater pressor responses to these laboratory stressors were associated with larger decrements in myocardial systolic and diastolic function in the older adults. Taken together, suboptimal LV adaptations to SNS stress may partly explain why acute heavy exertion (i.e., acute increases in afterload and myocardial O2 demand in the face of a sympathetic "brake" on the coronary vasculature) can trigger myocardial ischemia in certain individuals (44). Future studies evaluating the effects of healthy aging and aerobic exercise training on LV function during sympathetic stress are much needed.
AB - The use of TDI to quantify LV systolic and diastolic function is becoming more popular in clinical care as well as in physiological experiments. Our data indicate that Sm and Em are reduced in healthy older adults during IFHG and CPT. Furthermore, greater pressor responses to these laboratory stressors were associated with larger decrements in myocardial systolic and diastolic function in the older adults. Taken together, suboptimal LV adaptations to SNS stress may partly explain why acute heavy exertion (i.e., acute increases in afterload and myocardial O2 demand in the face of a sympathetic "brake" on the coronary vasculature) can trigger myocardial ischemia in certain individuals (44). Future studies evaluating the effects of healthy aging and aerobic exercise training on LV function during sympathetic stress are much needed.
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U2 - 10.1152/japplphysiol.01165.2012
DO - 10.1152/japplphysiol.01165.2012
M3 - Article
C2 - 23154996
AN - SCOPUS:84872328700
SN - 8750-7587
VL - 114
SP - 186
EP - 194
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 2
ER -