TY - JOUR
T1 - Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome
AU - Lynch, Thomas L.
AU - Kuster, Diederik W.D.
AU - Gonzalez, Beverly
AU - Balasubramanian, Neelam
AU - Nair, Nandini
AU - Day, Sharlene
AU - Calvino, Jenna E.
AU - Tan, Yanli
AU - Liebetrau, Christoph
AU - Troidl, Christian
AU - Hamm, Christian W.
AU - Güçlü, Ahmet
AU - McDonough, Barbara
AU - Marian, Ali J.
AU - van der Velden, Jolanda
AU - Seidman, Christine E.
AU - Huggins, Gordon S.
AU - Sadayappan, Sakthivel
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/4
Y1 - 2017/4
N2 - The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in cardiovascular disease patients. Importantly, cMyBP-C-AAbs were significantly detected in acute coronary syndrome patient sera upon arrival to the emergency department, particularly in ST-segment elevation myocardial infarction patients. Patients positive for cMyBP-C-AAbs had reduced left ventricular ejection fraction and elevated levels of clinical biomarkers of myocardial infarction. We conclude that cMyBP-C-AAbs may serve as early predictive indicators of deteriorating cardiac function and patient outcome in acute coronary syndrome patients prior to the infarction.
AB - The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in cardiovascular disease patients. Importantly, cMyBP-C-AAbs were significantly detected in acute coronary syndrome patient sera upon arrival to the emergency department, particularly in ST-segment elevation myocardial infarction patients. Patients positive for cMyBP-C-AAbs had reduced left ventricular ejection fraction and elevated levels of clinical biomarkers of myocardial infarction. We conclude that cMyBP-C-AAbs may serve as early predictive indicators of deteriorating cardiac function and patient outcome in acute coronary syndrome patients prior to the infarction.
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U2 - 10.1016/j.jacbts.2016.12.001
DO - 10.1016/j.jacbts.2016.12.001
M3 - Article
AN - SCOPUS:85018850192
SN - 2452-302X
VL - 2
SP - 122
EP - 131
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 2
ER -