Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Thomas L. Lynch; Diederik W.D. Kuster; Beverly Gonzalez; Neelam Balasubramanian; Nandini Nair; Sharlene Day; Jenna E. Calvino; Yanli Tan; Christoph Liebetrau; Christian Troidl; Christian W. Hamm; Ahmet Güçlü; Barbara McDonough; Ali J. Marian; Jolanda van der Velden; Christine E. Seidman; Gordon S. Huggins; Sakthivel Sadayappan

doi:10.1016/j.jacbts.2016.12.001

Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

Thomas L. Lynch, Diederik W.D. Kuster, Beverly Gonzalez, Neelam Balasubramanian, Nandini Nair, Sharlene Day, Jenna E. Calvino, Yanli Tan, Christoph Liebetrau, Christian Troidl, Christian W. Hamm, Ahmet Güçlü, Barbara McDonough, Ali J. Marian, Jolanda van der Velden, Christine E. Seidman, Gordon S. Huggins, Sakthivel Sadayappan

Department of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in cardiovascular disease patients. Importantly, cMyBP-C-AAbs were significantly detected in acute coronary syndrome patient sera upon arrival to the emergency department, particularly in ST-segment elevation myocardial infarction patients. Patients positive for cMyBP-C-AAbs had reduced left ventricular ejection fraction and elevated levels of clinical biomarkers of myocardial infarction. We conclude that cMyBP-C-AAbs may serve as early predictive indicators of deteriorating cardiac function and patient outcome in acute coronary syndrome patients prior to the infarction.

Original language	English (US)
Pages (from-to)	122-131
Number of pages	10
Journal	JACC: Basic to Translational Science
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2016.12.001
State	Published - Apr 2017

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jacbts.2016.12.001

Cite this

Lynch, T. L., Kuster, D. W. D., Gonzalez, B., Balasubramanian, N., Nair, N., Day, S., Calvino, J. E., Tan, Y., Liebetrau, C., Troidl, C., Hamm, C. W., Güçlü, A., McDonough, B., Marian, A. J., van der Velden, J., Seidman, C. E., Huggins, G. S., & Sadayappan, S. (2017). Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC: Basic to Translational Science, 2(2), 122-131. https://doi.org/10.1016/j.jacbts.2016.12.001

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title = "Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome",

abstract = "The degradation and release of cardiac myosin binding protein-C (cMyBP-C) upon cardiac damage may stimulate an inflammatory response and autoantibody (AAb) production. We determined whether the presence of cMyBP-C-AAbs associated with adverse cardiac function in cardiovascular disease patients. Importantly, cMyBP-C-AAbs were significantly detected in acute coronary syndrome patient sera upon arrival to the emergency department, particularly in ST-segment elevation myocardial infarction patients. Patients positive for cMyBP-C-AAbs had reduced left ventricular ejection fraction and elevated levels of clinical biomarkers of myocardial infarction. We conclude that cMyBP-C-AAbs may serve as early predictive indicators of deteriorating cardiac function and patient outcome in acute coronary syndrome patients prior to the infarction.",

author = "Lynch, {Thomas L.} and Kuster, {Diederik W.D.} and Beverly Gonzalez and Neelam Balasubramanian and Nandini Nair and Sharlene Day and Calvino, {Jenna E.} and Yanli Tan and Christoph Liebetrau and Christian Troidl and Hamm, {Christian W.} and Ahmet G{\"u}{\c c}l{\"u} and Barbara McDonough and Marian, {Ali J.} and {van der Velden}, Jolanda and Seidman, {Christine E.} and Huggins, {Gordon S.} and Sakthivel Sadayappan",

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doi = "10.1016/j.jacbts.2016.12.001",

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Lynch, TL, Kuster, DWD, Gonzalez, B, Balasubramanian, N, Nair, N, Day, S, Calvino, JE, Tan, Y, Liebetrau, C, Troidl, C, Hamm, CW, Güçlü, A, McDonough, B, Marian, AJ, van der Velden, J, Seidman, CE, Huggins, GS & Sadayappan, S 2017, 'Cardiac Myosin Binding Protein-C Autoantibodies Are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome', JACC: Basic to Translational Science, vol. 2, no. 2, pp. 122-131. https://doi.org/10.1016/j.jacbts.2016.12.001

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AU - Lynch, Thomas L.

AU - Kuster, Diederik W.D.

AU - Gonzalez, Beverly

AU - Balasubramanian, Neelam

AU - Nair, Nandini

AU - Day, Sharlene

AU - Calvino, Jenna E.

AU - Tan, Yanli

AU - Liebetrau, Christoph

AU - Troidl, Christian

AU - Hamm, Christian W.

AU - Güçlü, Ahmet

AU - McDonough, Barbara

AU - Marian, Ali J.

AU - van der Velden, Jolanda

AU - Seidman, Christine E.

AU - Huggins, Gordon S.

AU - Sadayappan, Sakthivel

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