Cardiorespiratory components of defense reaction elicited from paraventricular nucleus

Yu Fei Duan; Ray Winters; Philip M. McCabe; Edward J. Green; Ying Huang; Neil Schneiderman

doi:10.1016/S0031-9384(96)00410-6

Cardiorespiratory components of defense reaction elicited from paraventricular nucleus

Yu Fei Duan, Ray Winters, Philip M. McCabe, Edward J. Green, Ying Huang, Neil Schneiderman

Department of Psychiatry and Behavioral Health

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The present study was conducted to test the hypothesis that the paraventricular nucleus of the hypothalamus (PVN) is involved in the mediation or modulation of the cardiorespiratory components of the defense reaction (DR) in rabbits. Electrical stimulation of the PVN elicited increases in blood pressure and heart rate, hyperventilation, decreased blood flow to the visceral organs, and an increase in blood flow to the hindlimbs that was mediated by an atropine-sensitive vasodilation system. This response pattern is nearly identical to the one that is elicited by electrical stimulation of the hypothalamic defense area. In addition, the cardiomotor component of the baroreceptor reflex was observed to be suppressed during electrical stimulation of the PVN. Previous studies have shown that electrical stimulation of the hypothalamic defense area also leads to inhibition of the cardiomotor component of the baroreceptor reflex. The results of the present study provide evidence that the PVN is involved in the mediation or modulation of the defense reaction.

Original language	English (US)
Pages (from-to)	325-330
Number of pages	6
Journal	Physiology and Behavior
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/S0031-9384(96)00410-6
State	Published - Feb 1997

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Behavioral Neuroscience

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title = "Cardiorespiratory components of defense reaction elicited from paraventricular nucleus",

abstract = "The present study was conducted to test the hypothesis that the paraventricular nucleus of the hypothalamus (PVN) is involved in the mediation or modulation of the cardiorespiratory components of the defense reaction (DR) in rabbits. Electrical stimulation of the PVN elicited increases in blood pressure and heart rate, hyperventilation, decreased blood flow to the visceral organs, and an increase in blood flow to the hindlimbs that was mediated by an atropine-sensitive vasodilation system. This response pattern is nearly identical to the one that is elicited by electrical stimulation of the hypothalamic defense area. In addition, the cardiomotor component of the baroreceptor reflex was observed to be suppressed during electrical stimulation of the PVN. Previous studies have shown that electrical stimulation of the hypothalamic defense area also leads to inhibition of the cardiomotor component of the baroreceptor reflex. The results of the present study provide evidence that the PVN is involved in the mediation or modulation of the defense reaction.",

author = "Duan, {Yu Fei} and Ray Winters and McCabe, {Philip M.} and Green, {Edward J.} and Ying Huang and Neil Schneiderman",

note = "Funding Information: The present study was supported by NIH HL 36588 and HL 07426.",

year = "1997",

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doi = "10.1016/S0031-9384(96)00410-6",

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T1 - Cardiorespiratory components of defense reaction elicited from paraventricular nucleus

AU - Duan, Yu Fei

AU - Winters, Ray

AU - McCabe, Philip M.

AU - Green, Edward J.

AU - Huang, Ying

AU - Schneiderman, Neil

N1 - Funding Information: The present study was supported by NIH HL 36588 and HL 07426.

PY - 1997/2

Y1 - 1997/2

N2 - The present study was conducted to test the hypothesis that the paraventricular nucleus of the hypothalamus (PVN) is involved in the mediation or modulation of the cardiorespiratory components of the defense reaction (DR) in rabbits. Electrical stimulation of the PVN elicited increases in blood pressure and heart rate, hyperventilation, decreased blood flow to the visceral organs, and an increase in blood flow to the hindlimbs that was mediated by an atropine-sensitive vasodilation system. This response pattern is nearly identical to the one that is elicited by electrical stimulation of the hypothalamic defense area. In addition, the cardiomotor component of the baroreceptor reflex was observed to be suppressed during electrical stimulation of the PVN. Previous studies have shown that electrical stimulation of the hypothalamic defense area also leads to inhibition of the cardiomotor component of the baroreceptor reflex. The results of the present study provide evidence that the PVN is involved in the mediation or modulation of the defense reaction.

AB - The present study was conducted to test the hypothesis that the paraventricular nucleus of the hypothalamus (PVN) is involved in the mediation or modulation of the cardiorespiratory components of the defense reaction (DR) in rabbits. Electrical stimulation of the PVN elicited increases in blood pressure and heart rate, hyperventilation, decreased blood flow to the visceral organs, and an increase in blood flow to the hindlimbs that was mediated by an atropine-sensitive vasodilation system. This response pattern is nearly identical to the one that is elicited by electrical stimulation of the hypothalamic defense area. In addition, the cardiomotor component of the baroreceptor reflex was observed to be suppressed during electrical stimulation of the PVN. Previous studies have shown that electrical stimulation of the hypothalamic defense area also leads to inhibition of the cardiomotor component of the baroreceptor reflex. The results of the present study provide evidence that the PVN is involved in the mediation or modulation of the defense reaction.

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VL - 61

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EP - 330

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 2

ER -

Cardiorespiratory components of defense reaction elicited from paraventricular nucleus

Abstract

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