Cardiorespiratory Fitness and Cardiac Magnetic Resonance Imaging in Childhood Acute Lymphoblastic Leukemia Survivors

Maxime Caru, Daniel Curnier, Pierre Dubois, Matthias G. Friedrich, Gregor Andelfinger, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Delphine Périé

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Childhood acute lymphoblastic leukemia survivors’ anthracycline-induced cardiotoxicity could be prevented with good cardiorespiratory fitness levels and regular physical activity. This cross-sectional study aimed to assess the association between cardiorespiratory fitness and physical activity with cardiac magnetic resonance parameters. Methods: A total of 96 childhood acute lymphoblastic leukemia survivors underwent a maximal cardiopulmonary exercise test and answered physical activity questionnaires. We calculated the odds ratio of the preventive fraction of regular physical activity (≥150 min/wk) and adequate cardiorespiratory fitness levels (above the median ≥31.4 mL·kg−1·min−1) on cardiac magnetic resonance parameters (left ventricular [LV] and right ventricular [RV] morphological and functional parameters). Results: An adequate cardiorespiratory fitness was associated with a significant preventive fraction for LV (up to 84% for LV end-diastolic volume) and RV volumes (up to 88% for RV end-systolic volume). The adjusted analyses highlighted a preventive fraction of 36% to 91% between an adequate cardiorespiratory fitness and LV and RV parameters, late gadolinium enhancement fibrosis, and cardiac magnetic resonance relaxation times. No associations were reported with regular physical activity. Conclusions: This study provides additional evidence regarding the benefits of an adequate cardiorespiratory fitness level for childhood cancer survivors’ cardiac health.

Original languageEnglish (US)
Pages (from-to)522-530
Number of pages9
JournalJournal of Physical Activity and Health
Volume20
Issue number6
DOIs
StatePublished - 2023

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Public Health, Environmental and Occupational Health

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