TY - JOUR
T1 - Cardiorespiratory Fitness and Cardiac Magnetic Resonance Imaging in Childhood Acute Lymphoblastic Leukemia Survivors
AU - Caru, Maxime
AU - Curnier, Daniel
AU - Dubois, Pierre
AU - Friedrich, Matthias G.
AU - Andelfinger, Gregor
AU - Krajinovic, Maja
AU - Laverdière, Caroline
AU - Sinnett, Daniel
AU - Périé, Delphine
N1 - Funding Information:
This work was supported by the Institute of Cancer Research of the Canadian Institutes of Health Research, in collaboration with C17 Council, Canadian Cancer Society, Cancer Research Society, Garron Family Cancer Centre at the Hospital for Sick Children, Ontario Institute for Cancer Research, and Pediatric Oncology Group of Ontario. The authors also thank the Natural Sciences and Engineering Research Council of Canada and Polytechnique Montreal for the financial support, as well as researchers from the PETALE study for the opportunity to perform these complementary analyses in the childhood ALL survivors cohort. This research was supported in part by PhD study grants from the Cole Foundation, Fonds de Recherche du Québec—Santé, Sainte-Justine University Hospital Center Foundation and Foundation of Stars. This research was supported in part by the TransMedTech Excellence Postdoctoral Fellowship from the Canada First Research Excellence Fund through the TransMed-Tech Institute. The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors appreciate the assistance of Ariane Levesque (University of Montreal) for her review of the article in the English language.
Publisher Copyright:
© 2023 Human Kinetics, Inc.
PY - 2023
Y1 - 2023
N2 - Background: Childhood acute lymphoblastic leukemia survivors’ anthracycline-induced cardiotoxicity could be prevented with good cardiorespiratory fitness levels and regular physical activity. This cross-sectional study aimed to assess the association between cardiorespiratory fitness and physical activity with cardiac magnetic resonance parameters. Methods: A total of 96 childhood acute lymphoblastic leukemia survivors underwent a maximal cardiopulmonary exercise test and answered physical activity questionnaires. We calculated the odds ratio of the preventive fraction of regular physical activity (≥150 min/wk) and adequate cardiorespiratory fitness levels (above the median ≥31.4 mL·kg−1·min−1) on cardiac magnetic resonance parameters (left ventricular [LV] and right ventricular [RV] morphological and functional parameters). Results: An adequate cardiorespiratory fitness was associated with a significant preventive fraction for LV (up to 84% for LV end-diastolic volume) and RV volumes (up to 88% for RV end-systolic volume). The adjusted analyses highlighted a preventive fraction of 36% to 91% between an adequate cardiorespiratory fitness and LV and RV parameters, late gadolinium enhancement fibrosis, and cardiac magnetic resonance relaxation times. No associations were reported with regular physical activity. Conclusions: This study provides additional evidence regarding the benefits of an adequate cardiorespiratory fitness level for childhood cancer survivors’ cardiac health.
AB - Background: Childhood acute lymphoblastic leukemia survivors’ anthracycline-induced cardiotoxicity could be prevented with good cardiorespiratory fitness levels and regular physical activity. This cross-sectional study aimed to assess the association between cardiorespiratory fitness and physical activity with cardiac magnetic resonance parameters. Methods: A total of 96 childhood acute lymphoblastic leukemia survivors underwent a maximal cardiopulmonary exercise test and answered physical activity questionnaires. We calculated the odds ratio of the preventive fraction of regular physical activity (≥150 min/wk) and adequate cardiorespiratory fitness levels (above the median ≥31.4 mL·kg−1·min−1) on cardiac magnetic resonance parameters (left ventricular [LV] and right ventricular [RV] morphological and functional parameters). Results: An adequate cardiorespiratory fitness was associated with a significant preventive fraction for LV (up to 84% for LV end-diastolic volume) and RV volumes (up to 88% for RV end-systolic volume). The adjusted analyses highlighted a preventive fraction of 36% to 91% between an adequate cardiorespiratory fitness and LV and RV parameters, late gadolinium enhancement fibrosis, and cardiac magnetic resonance relaxation times. No associations were reported with regular physical activity. Conclusions: This study provides additional evidence regarding the benefits of an adequate cardiorespiratory fitness level for childhood cancer survivors’ cardiac health.
UR - https://www.scopus.com/pages/publications/85159268737
UR - https://www.scopus.com/pages/publications/85159268737#tab=citedBy
U2 - 10.1123/jpah.2022-0179
DO - 10.1123/jpah.2022-0179
M3 - Article
C2 - 36972702
AN - SCOPUS:85159268737
SN - 1543-3080
VL - 20
SP - 522
EP - 530
JO - Journal of Physical Activity and Health
JF - Journal of Physical Activity and Health
IS - 6
ER -
SDG 3 Good Health and Well-being