Case report and review of resolved fusariosis

Thomas N. Helm, David L. Longworth, Geraldine S. Hall, Brian J. Bolwell, Bernard Fernandez, Kenneth J. Tomecki

Research output: Contribution to journalReview articlepeer-review

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Erythematous macules, nonpalpable and palpable purpura, and flaccid pustules developed in a 59-year-old man with acute lymphocytic leukemia 8 days after reinduction chemotherapy with cytosine arabinoside and daunorubicin. Tissue and blood cultures grew Fusarium proliferatum, and a skin biopsy specimen revealed fungal vasculitis. Anemia and muscle weakness accompanied the disseminated infection, for which the patient received granulocyte transfusions and amphotericin B, ketoconazole, rifampin, and griseofulvin. Skin lesions and fungemia resolved with recovery of the bone marrow, and 51 days after the completion of his chemotherapy he returned home. If promptly recognized and aggressively treated, disseminated fusariosis is responsive to therapy. Infection with Fusarium species should be suspected in profoundly neutropenic patients in whom disseminated palpable purpura and myositis develop concomitantly.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Dermatology

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